Role of β-Catenin/TCF-4 Signaling in HIV Replication and Pathogenesis: Insights to Informing Novel Anti-HIV Molecular Therapeutics

被引：22
作者：
Henderson, Lisa J. [2 ,3 ]
Al-Harthi, Lena [1 ,2 ,3 ]
机构：
[1] Rush Univ, Med Ctr, Dept Immunol & Microbiol, Chicago, IL 60612 USA
[2] Rush Univ, Med Ctr, Dept Immunol & Microbiol, Chicago, IL 60607 USA
[3] Rush Univ, Med Ctr, Ctr AIDS Res, Chicago, IL 60607 USA
来源：
JOURNAL OF NEUROIMMUNE PHARMACOLOGY | 2011年 / 6卷 / 02期
关键词：
HIV neuropathogenesis; Astrocyte; Signaling pathway; IMMUNODEFICIENCY-VIRUS TYPE-1; SYNTHASE KINASE-3-BETA CONTRIBUTES; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; BETA-CATENIN; WNT/BETA-CATENIN; GAMMA-INTERFERON; VALPROIC ACID; WNT; LITHIUM;
D O I：
10.1007/s11481-011-9266-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A greater understanding of the interaction between HIV and host signaling pathways that restrict virus production may lead to new methods to purge virus from latent reservoirs and enhance survival/function of cells targeted by HIV. This review highlights the role of the Wnt/beta-catenin pathway as a host factor that represses HIV replication in multiple targets, especially those relevant to HIV in the central nervous system.
引用
收藏
页码：247 / 259
页数：13
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