Role of β-Catenin/TCF-4 Signaling in HIV Replication and Pathogenesis: Insights to Informing Novel Anti-HIV Molecular Therapeutics

被引：22
作者：
Henderson, Lisa J. [2 ,3 ]
Al-Harthi, Lena [1 ,2 ,3 ]
机构：
[1] Rush Univ, Med Ctr, Dept Immunol & Microbiol, Chicago, IL 60612 USA
[2] Rush Univ, Med Ctr, Dept Immunol & Microbiol, Chicago, IL 60607 USA
[3] Rush Univ, Med Ctr, Ctr AIDS Res, Chicago, IL 60607 USA
来源：
JOURNAL OF NEUROIMMUNE PHARMACOLOGY | 2011年 / 6卷 / 02期
关键词：
HIV neuropathogenesis; Astrocyte; Signaling pathway; IMMUNODEFICIENCY-VIRUS TYPE-1; SYNTHASE KINASE-3-BETA CONTRIBUTES; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; BETA-CATENIN; WNT/BETA-CATENIN; GAMMA-INTERFERON; VALPROIC ACID; WNT; LITHIUM;
D O I：
10.1007/s11481-011-9266-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A greater understanding of the interaction between HIV and host signaling pathways that restrict virus production may lead to new methods to purge virus from latent reservoirs and enhance survival/function of cells targeted by HIV. This review highlights the role of the Wnt/beta-catenin pathway as a host factor that represses HIV replication in multiple targets, especially those relevant to HIV in the central nervous system.
引用
收藏
页码：247 / 259
页数：13
相关论文
共 79 条
  • [1] Regulation of tau phosphorylation and protection against β-amyloid-induced neurodegeneration by lithium.: Possible implications for Alzheimer's disease
    Alvarez, G
    Muñoz-Montaño, JR
    Satrústegui, J
    Avila, J
    Bogónez, E
    Díaz-Nido, J
    [J]. BIPOLAR DISORDERS, 2002, 4 (03) : 153 - 165
  • [2] For the long run: Maintaining germinal niches in the adult brain
    Alvarez-Buylla, A
    Lim, DA
    [J]. NEURON, 2004, 41 (05) : 683 - 686
  • [3] Proximal events in Wnt signal transduction
    Angers, Stephane
    Moon, Randall T.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (07) : 468 - 477
  • [4] Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells
    Archin, Nancy M.
    Eron, Joseph J.
    Palmer, Sarah
    Hartmann-Duff, Anne
    Martinson, Jeffery A.
    Wiegand, Ann
    Bandarenko, Nicholas
    Schmitz, John L.
    Bosch, Ronald J.
    Landay, Alan L.
    Coffin, John M.
    Margolis, David M.
    [J]. AIDS, 2008, 22 (10) : 1131 - 1135
  • [5] Neuroprotection by estrogen in the brain: the mitochondrial compartment as presumed therapeutic target
    Arnold, Susanne
    Beyer, Cordian
    [J]. JOURNAL OF NEUROCHEMISTRY, 2009, 110 (01) : 1 - 11
  • [6] Gene Expression Profiles of HIV-1-Infected Glia and Brain: Toward Better Understanding of the Role of Astrocytes in HIV-1-Associated Neurocognitive Disorders
    Borjabad, Alejandra
    Brooks, Andrew I.
    Volsky, David J.
    [J]. JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2010, 5 (01) : 44 - 62
  • [7] Brass AL, 2008, SCIENCE, V319, P921, DOI 10.1126/science.1152725
  • [8] Highly productive infection with pseudotyped human immunodeficiency virus type 1 (HIV-1) indicates no intracellular restrictions to HIV-1 replication in primary human astrocytes
    Canki, M
    Thai, JNF
    Chao, W
    Ghorpade, A
    Potash, MJ
    Volsky, DJ
    [J]. JOURNAL OF VIROLOGY, 2001, 75 (17) : 7925 - 7933
  • [9] Gamma interferon primes productive human immunodeficiency virus infection in astrocytes
    Carroll-Anzinger, D
    Al-Harthi, L
    [J]. JOURNAL OF VIROLOGY, 2006, 80 (01) : 541 - 544
  • [10] Human immunodeficiency virus-restricted replication in astrocytes and the ability of gamma interferon to modulate this restriction are regulated by a downstream effector of the Wnt signaling pathway
    Carroll-Anzinger, Deborah
    Kumar, Anvita
    Adarichev, Vyacheslav
    Kashanchi, Fatah
    Al-Harthi, Lena
    [J]. JOURNAL OF VIROLOGY, 2007, 81 (11) : 5864 - 5871
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