Rosacea and its management: an overview

被引:96
作者
Gupta, AK
Chaudhry, MM
机构
[1] Sunnybrook & Womens Coll Hlth Sci Ctr, Dept Med, Div Dermatol, Toronto, ON, Canada
[2] Univ Toronto, Toronto, ON, Canada
[3] Mediprobe Res Inc, London, ON, Canada
关键词
azelaic acid; isotretinoin; management; metronidazole; rosacea; tetracycline;
D O I
10.1111/j.1468-3083.2005.01216.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background Rosacea is a chronic inflammatory disorder that affects 10% of the population. The prevalence of rosacea is highest among fair-skinned individuals, particularly those of Celtic and northern European descent. Since a cure for rosacea does not yet exist, management and treatment regimens are designed to suppress the inflammatory lesions, erythema, and to a lesser extent, the telangiectasia involved with rosacea. Objectives This review outlines the treatment options that are available to patients with rosacea. Methods Published literature involving the treatment or management of rosacea was examined and summarized. Results Patients who find that they blush and flush frequently, or have a family history of rosacea are advised to avoid the physiological and environmental stimuli that can cause increased facial redness. Topical agents such as metronidazole, azelaic acid cream or sulfur preparations are effective in managing rosacea. Patients who have progressed to erythematotelangiectatic and papulopustular rosacea may benefit from the use of an oral antibiotic, such as tetracycline, and in severe or recalcitrant cases, isotretinoin to bring the rosacea flare-up under control. Treatment with a topical agent, such as metronidazole, may help maintain remission. Patients with ocular involvement may benefit from a long-term course of an antibiotic and the use of metronidazole gel. A surgical alternative, laser therapy, is recommended for the treatment of telangiectasias and rhinophyma. Patients with distraught feelings due to their rosacea may consider cosmetic camouflage to cover the signs of rosacea. Conclusions With the wide variety of oral and topical agents available for the effective management of rosacea, patients no longer need to feel self-conscious because of their disorder.
引用
收藏
页码:273 / 285
页数:13
相关论文
共 86 条
[21]   Once-daily topical metronidazole cream formulations in the treatment of the papules and pustules of rosacea [J].
Dahl, MV ;
Jarratt, M ;
Kaplan, D ;
Tuley, MR ;
Baker, MD .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2001, 45 (05) :723-730
[22]   ARGON-LASER TREATMENT OF THE RED NOSE [J].
DICKEN, CH .
JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY, 1990, 16 (01) :33-36
[23]   TREATMENT OF THE RED NOSE WITH THE ARGON-LASER [J].
DICKEN, CH .
MAYO CLINIC PROCEEDINGS, 1986, 61 (11) :893-895
[24]   SURGICAL-TREATMENT OF RHINOPHYMA WITH THE SHAW SCALPEL [J].
EISEN, RF ;
KATZ, AE ;
BOHIGIAN, RK ;
GRANDE, DJ .
ARCHIVES OF DERMATOLOGY, 1986, 122 (03) :307-309
[25]   SPECTRUM OF RESULTS AFTER TREATMENT OF RHINOPHYMA WITH THE CARBON-DIOXIDE LASER [J].
ELAZHARY, RA ;
ROENIGK, RK ;
WANG, TD .
MAYO CLINIC PROCEEDINGS, 1991, 66 (09) :899-905
[26]   Efficacy of low-dose isotretinoin in patients with treatment-resistant rosacea [J].
Erdogan, FG ;
Yurtsever, P ;
Aksoy, D ;
Eskioglu, F .
ARCHIVES OF DERMATOLOGY, 1998, 134 (07) :884-885
[27]   A COMPARISON OF THE EFFICACY OF TOPICAL TRETINOIN AND LOW-DOSE ORAL ISOTRETINOIN IN ROSACEA [J].
ERTL, GA ;
LEVINE, N ;
KLIGMAN, AM .
ARCHIVES OF DERMATOLOGY, 1994, 130 (03) :319-324
[28]   EFFICACY OF DOXYCYCLINE AND TETRACYCLINE IN OCULAR ROSACEA [J].
FRUCHTPERY, J ;
SAGI, E ;
HEMO, I ;
EVERHADANI, P .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1993, 116 (01) :88-92
[29]  
GARNISJONES S, 1998, J CUTAN MED SURG S4, V2, P4
[30]   ISOTRETINOIN IN THE TREATMENT OF ACNE - HISTOLOGIC-CHANGES, SEBUM PRODUCTION, AND CLINICAL OBSERVATIONS [J].
GOLDSTEIN, JA ;
COMITE, H ;
MESCON, H ;
POCHI, PE .
ARCHIVES OF DERMATOLOGY, 1982, 118 (08) :555-558