BAP1 methylation: a prognostic marker of uveal melanoma metastasis

被引：12
作者：
Bakhoum, Mathieu F. [1 ,2 ]
Curtis, Ellis J. [3 ,4 ,5 ]
Goldbaum, Michael H. [2 ]
Mischel, Paul S. [4 ,5 ]
机构：
[1] Yale Univ, Sch Med, Dept Ophthalmol & Visual Sci, New Haven, CT 06510 USA
[2] Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA
[4] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA
[5] Stanford Univ, ChEM H, Stanford, CA 94305 USA
来源：
NPJ PRECISION ONCOLOGY | 2021年 / 5卷 / 01期
基金：
美国国家卫生研究院;
关键词：
EXPRESSION; MONOSOMY-3;
D O I：
10.1038/s41698-021-00226-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. Here, we show that assessment of BAP1 methylation is an accurate and readily clinically actionable assay to accurately identify high-risk uveal melanoma patients.
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页数：4
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