Development of HANABI, an ultrasonication-forced amyloid fibril inducer

被引：7

作者：

Goto, Yuji ^{[1
]}

Nakajima, Kichitaro ^{[1
]}

Yamaguchi, Keiichi ^{[1
]}

So, Masatomo ^{[2
]}

Ikenaka, Kensuke ^{[3
]}

Mochizuki, Hideki ^{[3
]}

Ogi, Hirotsugu ^{[4
]}

机构：

[1] Osaka Univ, Global Ctr Med Engn & Informat, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Inst Prot Res, 3-2 Yamadaoka, Suita, Osaka 5650871, Japan

[3] Osaka Univ, Grad Sch Med, Dept Neurol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[4] Osaka Univ, Grad Sch Engn, Suita, Osaka 5650871, Japan

来源：

NEUROCHEMISTRY INTERNATIONAL | 2022年 / 153卷

基金：

日本学术振兴会;

关键词：

alpha-synuclein; beta(2)-microglobulin; Amyloid fibril; Solubility; Supersaturation; Ultrasonication; ALPHA-SYNUCLEIN; CEREBROSPINAL-FLUID; CYCLIC AMPLIFICATION; ALZHEIMERS-DISEASE; PROTEIN; SUPERSATURATION; MECHANISM; CRYSTALLIZATION; BIOMARKERS; KINETICS;

D O I：

10.1016/j.neuint.2021.105270

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amyloid fibrils involved in amyloidoses are crystal-like aggregates, which are formed by breaking supersaturation of denatured proteins. Ultrasonication is an efficient method of agitation for breaking supersaturation and thus inducing amyloid fibrils. By combining an ultrasonicator and a microplate reader, we developed the HANABI (HANdai Amyloid Burst Inducer) system that enables high-throughput analysis of amyloid fibril formation. Among high-throughput approaches of amyloid fibril assays, the HANABI system has advantages in accelerating and detecting spontaneous amyloid fibril formation. HANABI is also powerful for amplifying a tiny amount of preformed amyloid fibrils by seeding. Thus, HANABI will contribute to creating therapeutic strategies against amyloidoses by identifying their biomarkers.

引用

页数：9

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