Seasonality of diagnosis of type 1 diabetes mellitus in the Netherlands (Young Dudes-2)

被引：7
作者：
Spaans, Engelina A. J. M. [1 ,2 ]
van Dijk, Peter R. [1 ]
Groenier, Klaas H. [1 ,3 ]
Brand, Paul L. P. [2 ,4 ]
Reeser, Maarten H. [5 ]
Bilo, Henk J. G. [1 ,6 ]
Kleefstra, Nanne [1 ,6 ,7 ]
机构：
[1] Isala, Ctr Diabet, POB 10400, NL-8000 GK Zwolle, Netherlands
[2] Isala, Princess Amalia Childrens Clin, NL-8000 GK Zwolle, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Gen Practice, Groningen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, UMCG Postgrad Sch Med, Groningen, Netherlands
[5] Juliana Childrens Hosp, Haga Teaching Hosp, The Hague, Netherlands
[6] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands
[7] Langerhans Med Res Grp, Zwolle, Netherlands
来源：
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2016年 / 29卷 / 06期
关键词：
diagnosis; seasonality; type 1 diabetes mellitus; CHILDHOOD IDDM; VITAMIN-D; CHILDREN; BIRTH; VIRUSES; ASSOCIATION; NATIONWIDE; ETIOLOGY; DISEASE; GERMANY;
D O I：
10.1515/jpem-2015-0435
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: The aim of this study was to investigate seasonality in the initial presentation of type 1 diabetes mellitus (T1DM) among Dutch children. Methods: Observational, nationwide study in the Netherlands. Using the national registry for both healthcare reimbursement and pharmaceutical care, data of all Dutch children (aged 0-14 years) with a diagnosis of T1DM in the period 2009-2011 were obtained. Results: During the study period (2009-2011) an average annual number of 2.909.537 children aged 0-14 lived in the Netherlands and 676 children were diagnosed with T1DM per year, translating into an annual incidence rate (IR) of T1DM of 23.2 per hundred thousand children (ptc). The annual IR differed significantly (p = 0.03) between seasons: 6.4 ptc in winter, 4.9 ptc in spring, 5.4 ptc in summer and 6.6 ptc in autumn. This pattern was present within both boys and girls Conclusions: Among Dutch children aged 0-14 years, there is seasonality in the of T1DM with a peak incidence in autumn and winter.
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收藏
页码：657 / 661
页数：5
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