Modeling of 24-Hour Glucose and Insulin Profiles of Patients With Type 2 Diabetes

被引：38

作者：

Jauslin, Petra M. ^{[1
,2
]}

Frey, Nicolas

Karlsson, Mats O. ^{[2
]}

机构：

[1] F Hoffmann La Roche Ltd, Dept Biomath, Modeling & Simulat Grp, Biomath Modeling & Simulat,PDIM M,Biomath, CH-4070 Basel, Switzerland

[2] Uppsala Univ, Dept Pharmaceut Biosci, Div Pharmacokinet & Drug Therapy, S-75105 Uppsala, Sweden

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 2011年 / 51卷 / 02期

关键词：

NONMEM; glucose homeostasis; type; 2; diabetes; meal test; circadian rhythm;

D O I：

10.1177/0091270010362536

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A model able to simultaneously characterize and simulate 24-hour glucose and insulin profiles following multiple meal tests was developed, extending an integrated glucose-insulin model for oral glucose tolerance tests that was previously published. The analysis was based on glucose and insulin measurements from 59 placebo-treated patients with type 2 diabetes. Circadian variations in glucose homeostasis were assessed on relevant parameters based on literature review. They were best described by a nighttime dip in insulin secretion between approximately 9 p.m. and 5 a.m. using a modulator function. The integrated glucose-insulin model has thus been shown to be applicable to real-life situations determined by multiple meals over the course of a day. This provides the basis for the analysis and simulation of long-term glucose and insulin data. The model may also prove useful for understanding antidiabetic drug actions and requirements in the context of circadian changes in glucose-insulin regulation.

引用

页码：153 / 164

页数：12

共 46 条

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