Comparison of the Performance of Two Different Spectral-Domain Optical Coherence Tomography Angiography Devices in Clinical Practice

Purpose: To compare the performance of two different spectral-domain optical coherence tomography angiography (OCTA) devices in clinical practice by evaluating examination execution time and the number of motion artifacts per image. Methods: Seventy-six patients affected by different ocular diseases and 13 healthy subjects consecutively underwent assessments by two different OCTA devices: Angio-Plex (Zeiss Meditec, Inc., Dublin, Calif., USA) and AngioVue (OptoVue, Inc., Fremont, Calif., USA). Two different operators (L.A.D.V. and L.B.) measured execution times, excluded low quality images, and counted the number of motion artifacts per image. Results: The mean execution time was shorter with AngioPlex than with AngioVue for all subjects (3 min 32 s +/- 1 min 45 s vs. 4 min 35 s +/- 1 min 11 s; p < 0.0001), for the healthy subjects (2 min 31 s +/- 45 s vs. 4 min 1 s +/- 53 s; p = 0.003), and for the patients (3 min 44 s +/- 1 min 48 s vs. 4 min 42 s +/- 1 min 13 s; p < 0.0001). The percentages of available images, low-signal-strength images, and images impossible to analyze of the total acquired images obtained using AngioPlex or AngioVue were 85, 6, and 9% and 56, 29, and 15%, respectively. The mean number of motion artifacts was significantly lower in images obtained using AngioPlex than in images obtained using AngioVue for all patients (6.5 +/- 5.9 vs. 12.6 +/- 8.5; p < 0.0001), for the healthy subjects (6.5 +/- 4.6 vs. 10.9 +/- 7.9; p = 0.0009), and for the patients (6.6 +/- 6.3 vs. 13.1 +/- 8.7; p < 0.0001). There was no correlation between the number of artifacts and execution time or patients' age. Conclusion: AngioPlex and AngioVue are useful devices in clinical practice. AngioPlex requires a shorter execution time and provides a higher number of images available for analysis with fewer motion artifacts. (C) 2016 S. Ka rger AG, Basel