Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and Significance

被引：27
|
作者：
Pu, Wenchen [1 ]
Zheng, Yuanyuan [1 ]
Peng, Yong [1 ]
机构：
[1] Sichuan Univ, Collaborat Innovat Ctr Biotherapy, West China Hosp, Lab Mol Oncol,State Key Lab Biotherapy & Canc Ctr, Chengdu, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2020年 / 8卷
基金：
中国国家自然科学基金;
关键词：
Pin1; PPIase isomerase; phosphorylation; cis-trans isomerization; cancer hallmarks; NF-KAPPA-B; CIS-TRANS ISOMERIZATION; TUMOR-SUPPRESSOR; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; PROMYELOCYTIC LEUKEMIA; NUCLEAR TRANSLOCATION; MICRORNA BIOGENESIS; PROSTATE-CANCER; RETINOIC ACID;
D O I：
10.3389/fcell.2020.00168
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is an evolutionally conserved and unique enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif and, subsequently, induces the conformational change of its substrates. Mounting evidence has demonstrated that Pin1 is widely overexpressed and/or overactivated in cancer, exerting a critical influence on tumor initiation and progression via regulation of the biological activity, protein degradation, or nucleus-cytoplasmic distribution of its substrates. Moreover, Pin1 participates in the cancer hallmarks through activating some oncogenes and growth enhancers, or inactivating some tumor suppressors and growth inhibitors, suggesting that Pin1 could be an attractive target for cancer therapy. In this review, we summarize the findings on the dysregulation, mechanisms, and biological functions of Pin1 in cancer cells, and also discuss the significance and potential applications of Pin1 dysregulation in human cancer.
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页数：11
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