Solubility and thermodynamic properties of mesalazine in {2-propanol + water} mixtures at various temperatures

被引：19

作者：

Agha, Elnaz Mazaher Haji ^{[1
]}

Barzegar-Jalali, Mohammad ^{[2
,3
]}

Adibkia, Khosro ^{[2
,3
]}

Hemmati, Salar ^{[1
]}

Martinez, Fleming ^{[4
]}

Jouyban, Abolghasem ^{[3
,5
,6
]}

机构：

[1] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[3] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[4] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fisicoquim,Sede Bogota, Cra 30 45-03, Bogota, DC, Colombia

[5] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran

[6] Univ Tehran Med Sci, Digest Dis Res Inst, Tehran, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2020年 / 301卷

关键词：

Solubility; Mesalazine; 2-Propanol; Jouyban-Acree model; Thermodynamics; Preferential solvation; VAPOR-LIQUID-EQUILIBRIUM; PREFERENTIAL SOLVATION; ANTIOXIDANT ACTIVITY; DIFFERENT SOLVENTS; PROPYLENE-GLYCOL; COSOLVENT; WATER; MIXTURES; ACID; EXPRESSION;

D O I：

10.1016/j.molliq.2020.112474

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The solubility of mesalazine in presence of 2-propanol as cosolvent in aqueous media was reported at T = (293.2 to 313.2) K. It was observed that the solubility of mesalazine is maximal in the 0.4 weight fraction of 2-propanol in the binary solvents. The performances of mathematical models of Jouyban-Acree, Apelblat-Jouyban-Acree, Jouyban-Acree-van't Hoff, modified Wilson, combined nearly ideal binary solvent/Redlich-Kister, UNIQUAC, NRTL and Wilson models in the solubility data representation were investigated. Two versions of Yalkowsky model were employed to estimate the solubility data. Dissolution and mixing apparent thermodynamic functions for mesalazine in studied solvents were also evaluated. Moreover, by means of inverse Kirkwood-Buff integrals method it is demonstrated that this drug is preferentially solvated by water in all the mixtures. (C) 2020 Elsevier B.V. All rights reserved.

引用

页数：8

共 40 条

[1] STATISTICAL THERMODYNAMICS OF LIQUID-MIXTURES - NEW EXPRESSION FOR EXCESS GIBBS ENERGY OF PARTLY OR COMPLETELY MISCIBLE SYSTEMS [J].

ABRAMS, DS ;

PRAUSNITZ, JM .

AICHE JOURNAL, 1975, 21 (01) :116-128

[2]

Acree W, 2012, TOXICITY AND DRUG TESTING, P1, DOI 10.5772/1976

[3] MATHEMATICAL REPRESENTATION OF THERMODYNAMIC PROPERTIES .2. DERIVATION OF THE COMBINED NEARLY IDEAL BINARY SOLVENT (NIBS) REDLICH-KISTER MATHEMATICAL REPRESENTATION FROM A 2-BODY AND 3-BODY INTERACTIONAL MIXING MODEL [J].

ACREE, WE .

THERMOCHIMICA ACTA, 1992, 198 (01) :71-79

[4] Individually administered or co-prescribed thiopurines and mesalamines for inflammatory bowel disease [J].

Actis, Giovanni C. ;

Pellicano, Rinaldo ;

Rizzetto, Mario ;

Ayoubi, Muhammad ;

Leone, Nicola ;

Tappero, Gianfranco ;

Pazienza, Paola ;

Rosina, Floriano .

WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (12) :1420-1426

[5] Mesalazine solubility in the binary mixtures of ethanol and water at various temperatures [J].

Alvani-Alamdari, Sima ;

Rezaei, Homa ;

Rahimpour, Elaheh ;

Hemmati, Salar ;

Martinez, Fleming ;

Barzegar-Jalali, Mohammad ;

Jouyban, Abolghasem .

PHYSICS AND CHEMISTRY OF LIQUIDS, 2021, 59 (01) :12-25

[6]

[Anonymous], [No title captured]

[7] Solubilities of o-acetylsalicylic, 4-aminosalicylic, 3,5-dinitrosalicylic, and p-toluic acid, and magnesium-DL-aspartate in water from T = (278 to 348) K [J].

Apelblat, A ;

Manzurola, E .

JOURNAL OF CHEMICAL THERMODYNAMICS, 1999, 31 (01) :85-91

[8] The solubility of ketoconazole in binary carbitol plus water mixtures at T = (293.2-313.2) K [J].

Barzegar-Jalali, Mohammad ;

Agha, Elnaz Mazaher Haji ;

Adibkia, Khosro ;

Martinez, Fleming ;

Jouyban, Abolghasem .

JOURNAL OF MOLECULAR LIQUIDS, 2020, 297 (297)

[9] INFLUENCE OF PROPYLENE-GLYCOL AS COSOLVENT ON MECHANISMS OF DRUG TRANSPORT FROM HYDROGELS [J].

BENDAS, B ;

SCHMALFUSS, U ;

NEUBERT, R .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 116 (01) :19-30

[10] Solid-liquid equilibria for systems containing 1-butyl-3-methylimidazolium chloride [J].

Domanska, U ;

Bogel-Lukasik, E .

FLUID PHASE EQUILIBRIA, 2004, 218 (01) :123-129

← 1 2 3 4 →