The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation

被引：3144

作者：

DeBerardinis, Ralph J. ^{[1
,2
]}

Lum, Julian J. ^{[1
]}

Hatzivassiliou, Georgia ^{[1
]}

Thompson, Craig B. ^{[1
]}

机构：

[1] Univ Penn, Abramson Canc Ctr, Dept Canc Biol, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

来源：

CELL METABOLISM | 2008年 / 7卷 / 01期

关键词：

D O I：

10.1016/j.cmet.2007.10.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising that metabolic activities in proliferating cells are fundamentally different from those in nonproliferating cells. This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types. We also consider regulation of these fluxes by cellular mediators of signal transduction and gene expression, including the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR system, hypoxia-inducible factor 1 (HIF-1), and Myc, during physiologic cell proliferation and tumorigenesis.

引用

页码：11 / 20

页数：10

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