Novel polymorphisms of the growth hormone gene and their effect on growth traits in Chinese goats

被引：25
|
作者：
An, X. P. [1 ]
Hou, J. X. [1 ]
Wang, L. X. [1 ]
Li, G. [1 ]
Wang, J. G. [1 ]
Song, Y. X. [1 ]
Zhou, G. Q. [1 ]
Han, D. [1 ]
Ling, L. [1 ]
Cao, B. Y. [1 ]
机构：
[1] NW A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
来源：
MEAT SCIENCE | 2010年 / 86卷 / 03期
关键词：
GH; Polymorphisms; Growth traits; Goat; Linkage disequilibrium; LINKAGE DISEQUILIBRIUM; NUCLEOTIDE POLYMORPHISM; CARCASS CHARACTERISTICS; SHORT STATURE; MEAT QUALITY; ASSOCIATION; MARKERS; SINGLE; SSCP; SOMATOTROPIN;
D O I：
10.1016/j.meatsci.2010.06.018
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The polymorphisms of the growth hormone (GH) gene were analyzed in 686 individuals from four goat populations, Three haplotypes (A, B and C) and three observed genotypes (AA. AB and AC) were detected at the P2 locus, and three haplotypes (E, F and G) and three observed genotypes (EE. EF and EG) were also detected at the P4 locus. In addition, five single nucleotide polymorphisms (SNPs)-A112G, C142T (Gly>Ser), C214T (P2 locus), C266A (Pro>His) and C214T (P4 locus, Arg>Trp), were identified by GH gene sequencing and PCR-SSCP analysis. The SNPs loci were in Hardy-Weinberg disequilibrium in three goat populations (P<0.05). Association of polymorphisms with growth traits was done in BG, F1 and F1 populations, which were shown to be associated with growth traits in three goat populations. The SNPs in the goat GH gene had significant effects on growth traits (P<0.05). suggesting that the GH gene is a strong candidate gene that affects growth traits in goat. (C) 2010 The American Meat Science Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：758 / 763
页数：6
相关论文
共 50 条
  • [41] GnRHR gene polymorphisms and their effects on reproductive performance in Chinese goats
    An, X. P.
    Han, D.
    Hou, J. X.
    Li, G.
    Wang, J. G.
    Yang, M. M.
    Song, Y. X.
    Zhou, G. Q.
    Wang, Y. N.
    Ling, L.
    Yan, Q. M.
    Cao, B. Y.
    SMALL RUMINANT RESEARCH, 2009, 85 (2-3) : 130 - 134
  • [42] Effect of GH gene polymorphism on growth traits in goats of Meghalaya's subtropical hilly region
    Kumar, Rakesh
    Kadirvel, G.
    Khargharia, G.
    Das, Meena
    Singh, Mahak
    Singh, Vinay
    INDIAN JOURNAL OF ANIMAL SCIENCES, 2024, 94 (11): : 953 - 959
  • [43] One novel SNP of growth hormone gene and its associations with growth and carcass traits in ducks
    Wu, Y.
    Pan, A. L.
    Pi, J. S.
    Pu, Y. J.
    Du, J. P.
    Liang, Z. H.
    Shen, J.
    MOLECULAR BIOLOGY REPORTS, 2012, 39 (08) : 8027 - 8033
  • [44] Novel Single Nucleotide Polymorphisms of the Caprine PC1 Gene and Association with Growth Traits
    Sun, Jiajie
    Zhang, Chunlei
    Fang, Xingtang
    Lei, Chuzhao
    Lan, Xianyong
    Chen, Hong
    BIOCHEMICAL GENETICS, 2010, 48 (9-10) : 779 - 788
  • [45] Novel Single Nucleotide Polymorphisms of the Caprine PC1 Gene and Association with Growth Traits
    Jiajie Sun
    Chunlei Zhang
    Xingtang Fang
    Chuzhao Lei
    Xianyong Lan
    Hong Chen
    Biochemical Genetics, 2010, 48 : 779 - 788
  • [46] TWO NOVEL INSERTION/DELETION VARIANTS OF THE CRTC3 GENE AND THEIR EFFECTS ON GROWTH TRAITS IN FOUR DIFFERENT CHINESE SHEEP BREEDS
    He, S.
    Zhao, H.
    Wang, S.
    Zhu, Y.
    Yu, X.
    Sun, X.
    JOURNAL OF ANIMAL AND PLANT SCIENCES, 2019, 29 (05): : 1228 - 1237
  • [47] The novel coding region SNPs of PPARGC1A gene and their associations with growth traits in Chinese native cattle
    Li, Mijie
    Liu, Mei
    Liu, Dong
    Lan, Xianyong
    Lei, Chuzhao
    Chen, Hong
    MOLECULAR BIOLOGY REPORTS, 2014, 41 (01) : 39 - 44
  • [48] PCR-RFLP Polymorphism of Growth Hormone Gene and Its Association with Growth and Morphometric Traits in Ganjam and Baigani Goats of Odisha
    Aradhana, A.
    Karna, D. K.
    Nayak, G. D.
    Sahoo, N.
    Sahoo, L. K.
    Behera, B. K.
    INDIAN JOURNAL OF ANIMAL RESEARCH, 2021, 55 (04) : 384 - 388
  • [49] Single nucleotide polymorphisms in intron 1 and intron 2 of Larimichthys crocea growth hormone gene are correlated with growth traits
    Ni Jing
    You Feng
    Xu Jianhe
    Xu Dongdong
    Wen Aiyun
    Wu Zhihao
    Xu Yongli
    Zhang Peijun
    CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2012, 30 (02): : 279 - 285
  • [50] Genetic variants in BMP8B gene are associated with growth traits in Chinese native cattle
    Cao, Xiu-Kai
    Wang, Jing
    Lan, Xian-Yong
    Lei, Chu-Zhao
    Zhang, Chun-Lei
    Qi, Xing-Lei
    Chen, Hong
    GENE, 2013, 532 (01) : 108 - 113
12345