Novel polymorphisms of the growth hormone gene and their effect on growth traits in Chinese goats

被引：25
|
作者：
An, X. P. [1 ]
Hou, J. X. [1 ]
Wang, L. X. [1 ]
Li, G. [1 ]
Wang, J. G. [1 ]
Song, Y. X. [1 ]
Zhou, G. Q. [1 ]
Han, D. [1 ]
Ling, L. [1 ]
Cao, B. Y. [1 ]
机构：
[1] NW A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
来源：
MEAT SCIENCE | 2010年 / 86卷 / 03期
关键词：
GH; Polymorphisms; Growth traits; Goat; Linkage disequilibrium; LINKAGE DISEQUILIBRIUM; NUCLEOTIDE POLYMORPHISM; CARCASS CHARACTERISTICS; SHORT STATURE; MEAT QUALITY; ASSOCIATION; MARKERS; SINGLE; SSCP; SOMATOTROPIN;
D O I：
10.1016/j.meatsci.2010.06.018
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The polymorphisms of the growth hormone (GH) gene were analyzed in 686 individuals from four goat populations, Three haplotypes (A, B and C) and three observed genotypes (AA. AB and AC) were detected at the P2 locus, and three haplotypes (E, F and G) and three observed genotypes (EE. EF and EG) were also detected at the P4 locus. In addition, five single nucleotide polymorphisms (SNPs)-A112G, C142T (Gly>Ser), C214T (P2 locus), C266A (Pro>His) and C214T (P4 locus, Arg>Trp), were identified by GH gene sequencing and PCR-SSCP analysis. The SNPs loci were in Hardy-Weinberg disequilibrium in three goat populations (P<0.05). Association of polymorphisms with growth traits was done in BG, F1 and F1 populations, which were shown to be associated with growth traits in three goat populations. The SNPs in the goat GH gene had significant effects on growth traits (P<0.05). suggesting that the GH gene is a strong candidate gene that affects growth traits in goat. (C) 2010 The American Meat Science Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：758 / 763
页数：6
相关论文
共 50 条
  • [21] Genetic variability of growth hormone gene and its association with growth traits in Sirohi breed of goat
    Kumar, S.
    Dixit, S. P.
    Gupta, S. C.
    Vyas, M. K.
    Kaur, Jagdeep
    INDIAN JOURNAL OF ANIMAL SCIENCES, 2011, 81 (03): : 272 - 275
  • [22] Association analysis of novel SNPs in exon 10 of the growth hormone receptor gene with growth traits in Indian sheep
    Sahu, Amiya R.
    Jeichitra, Veerasamy
    Rajendran, Ramanujam
    Raja, Angamuthu
    VETERINARSKI ARHIV, 2020, 90 (06) : 593 - 602
  • [23] The novel SNPs of leptin gene and their associations with growth traits in Chinese Nanjiang Yellow goat
    Wang, Cen
    Zhang, Hao
    Niu, Lili
    Guo, Jiazhong
    Jia, Xianbo
    Wang, Linjie
    Li, Li
    Zhang, Hongping
    Zhong, Tao
    GENE, 2015, 572 (01) : 35 - 41
  • [24] Haplotypes and effects on growth traits of bovine Wnt7a gene in Chinese Qinchuan cattle
    Xue, Jing
    Sun, Yujia
    Guo, Wenjiao
    Yang, Ziqi
    Tian, Huibin
    Zhang, Chunlei
    Lei, Chuzhao
    Lan, Xianyong
    Chen, Hong
    GENE, 2013, 524 (02) : 241 - 245
  • [25] The Prophet of PIT1 Gene Variation and its Effect on Growth Traits in Chinese Indigeous Goat
    Xu, T. S.
    Liu, J. B.
    Yao, D. W.
    Cai, H. F.
    Chen, H.
    Zhou, H. L.
    Lan, X. Y.
    JOURNAL OF ANIMAL AND VETERINARY ADVANCES, 2010, 9 (23): : 2940 - 2946
  • [26] NOVEL 16-BP INSERTION/DELETION VARIANT OF ZNF132 GENE AND ITS INFLUENCE ON GROWTH TRAITS IN GOATS
    Wang, X. Y.
    Yang, Q.
    Luo, J.
    Wang, Y.
    Feng, Q.
    Zhang, Z. H.
    Lei, C. Z.
    Chen, H.
    Lan, X. Y.
    Journal of Animal and Plant Sciences, 2016, 26 (06): : 1813 - 1818
  • [27] Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)
    Tian, Changxu
    Yang, Min
    Lv, Liyuan
    Yuan, Yongchao
    Liang, Xufang
    Guo, Wenjie
    Song, Yi
    Zhao, Cheng
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (04) : 7029 - 7036
  • [28] Single nucleotide polymorphisms of growth hormone gene in cattle and their association with growth traits: a systematic review
    Bila, Lubabalo
    Malatji, Dikeledi Petunia
    Tyasi, Thobela Louis
    TROPICAL ANIMAL HEALTH AND PRODUCTION, 2024, 56 (04)
  • [29] Identification of Single Nucleotide Polymorphisms (SNPs) of the Bovine Growth Hormone (bGH) Gene Associated with Growth and Carcass Traits in Hanwoo
    Lee, Ji-Hong
    Lee, Yun-Mi
    Lee, Jea-Young
    Oh, Dong-Yep
    Jeong, Dae-Jin
    Kim, Jong-Joo
    ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 2013, 26 (10): : 1359 - 1364
  • [30] Effects of genetic variability of the dairy goat growth hormone releasing hormone receptor (GHRHR) gene on growth traits
    Liu, Yanli
    Lan, Xianyong
    Qu, Yujiao
    Li, Zhuanjian
    Chen, Zhongqi
    Lei, Chuzhao
    Fang, Xingtang
    Chen, Hong
    MOLECULAR BIOLOGY REPORTS, 2011, 38 (01) : 539 - 544
12345