Hairpin formation and elongation of biomolecules

被引：75

作者：

Montanari, A ^{[1
]}

Mézard, M

机构：

[1] Scuola Normale Super Pisa, I-56100 Pisa, Italy

[2] Sezione Pisa, Ist Nazl Fis Nucl, I-56100 Pisa, Italy

[3] Univ Paris 11, Lab Phys Theor & Modeles Stat, F-91405 Orsay, France

来源：

PHYSICAL REVIEW LETTERS | 2001年 / 86卷 / 10期

关键词：

D O I：

10.1103/PhysRevLett.86.2178

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We introduce a model of thermalized conformations in space of RNA - or single stranded DNA - molecules, which includes the possibility of hairpin formation. This model contains the usual secondary structure information, but extends it to the study of one element of the ternary structure. namely the end-to-end distance. The computed force-elongation characteristics are in good agreement with sonic recent measurements on single stranded DNA molecules.

引用

收藏

页码：2178 / 2181

页数：4

相关论文

共 22 条

[1] Stretched and overwound DNA forms a Pauling-like structure with exposed bases [J].

Allemand, JF ;

Bensimon, D ;

Lavery, R ;

Croquette, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (24) :14152-14157

[2] DNA strand separation studied by single molecule force measurements [J].

Bockelmann, U ;

Essevaz-Roulet, B ;

Heslot, F .

PHYSICAL REVIEW E, 1998, 58 (02) :2386-2394

[3] RNA secondary structure formation: A solvable model of heteropolymer folding [J].

Bundschuh, R ;

Hwa, T .

PHYSICAL REVIEW LETTERS, 1999, 83 (07) :1479-1482

[4] ENTROPIC ELASTICITY OF LAMBDA-PHAGE DNA [J].

BUSTAMANTE, C ;

MARKO, JF ;

SIGGIA, ED ;

SMITH, S .

SCIENCE, 1994, 265 (5178) :1599-1600

[5] STATISTICAL THERMODYNAMICS OF DOUBLE-STRANDED POLYMER-MOLECULES [J].

CHEN, SJ ;

DILL, KA .

JOURNAL OF CHEMICAL PHYSICS, 1995, 103 (13) :5802-5813

[6] DNA: An extensible molecule [J].

Cluzel, P ;

Lebrun, A ;

Heller, C ;

Lavery, R ;

Viovy, JL ;

Chatenay, D ;

Caron, F .

SCIENCE, 1996, 271 (5250) :792-794

[7]

DESSINGES MN, IN PRESS

[8] STATISTICS OF RNA SECONDARY STRUCTURES [J].

FONTANA, W ;

KONINGS, DAM ;

STADLER, PF ;

SCHUSTER, P .

BIOPOLYMERS, 1993, 33 (09) :1389-1404

[9]

HIGGS PG, 1993, J PHYS I, V3, P43, DOI 10.1051/jp1:1993116

[10] Overlaps between RNA secondary structures [J].

Higgs, PG .

PHYSICAL REVIEW LETTERS, 1996, 76 (04) :704-707