Critical role of KRAS mutation in pancreatic ductal adenocarcinoma

被引：18

作者：

Fan, Zhiyao ^{[1
,2
,3
,4
]}

Fan, Kun ^{[1
,2
,3
,4
]}

Yang, Chao ^{[1
,2
,3
,4
]}

Huang, Qiuyi ^{[1
,2
,3
,4
]}

Gong, Yitao ^{[1
,2
,3
,4
]}

Cheng, He ^{[1
,2
,3
,4
]}

Jin, Kaizhou ^{[1
,2
,3
,4
]}

Liu, Chen ^{[1
,2
,3
,4
]}

Ni, Quanxing ^{[1
,2
,3
,4
]}

Yu, Xianjun ^{[1
,2
,3
,4
]}

Luo, Guopei ^{[1
,2
,3
,4
]}

机构：

[1] Fudan Univ, Dept Pancreat Surg, Shanghai Canc Ctr, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

[3] Shanghai Pancreat Canc Inst, Shanghai 200032, Peoples R China

[4] Fudan Univ, Pancreat Canc Inst, Shanghai 200032, Peoples R China

来源：

TRANSLATIONAL CANCER RESEARCH | 2018年 / 7卷 / 06期

关键词：

KRAS; pancreatic ductal adenocarcinoma (PDAC); microenvironment; metabolic reprogramming; diagnosis; prognosis; therapeutic; FINE-NEEDLE-ASPIRATION; ONCOGENIC KRAS; MUTANT KRAS; THERAPEUTIC RESPONSE; POTENTIAL BIOMARKERS; SOMATIC MUTATIONS; TARGETING KRAS; IN-VITRO; CANCER; DNA;

D O I：

10.21037/tcr.2018.10.19

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers worldwide. Little progress has been made in recent years concerning its diagnosis and treatment. Genetic alterations can be found in approximately 97% of PDAC cases. Mutations in the KRAS gene, which encodes the KRAS protein that regulates cell proliferation, differentiation, and apoptosis via activation of downstream signal transduction pathways, occur most frequently. KRAS plays a pivotal role in modulating the tumor microenvironment in PDAC patients. Additionally, KRAS can regulate metabolic changes in PDAC cells in a variety of ways. Although previous studies have shown that KRAS mutation detection can be used for early diagnosis and to predict the prognosis of PDAC patients, and many paths have been proposed to suppress the effects of KRAS, there is still no single pathway that leads to effective treatment of KRAS-mutant PDAC. This review summarizes the role of KRAS mutation in PDAC and examines the association between KRAS mutation and clinical applications.

引用

页码：1728 / 1736

页数：9

共 81 条

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