Spontaneous Resolution of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

Secondary hemophagocytic lymphohistiocytosis (sHLH) is a reactive, proliferative disorder of the immune system resulting in lymphohistiocytic proliferation, hemophagocytosis, and cytokine dysregulanon The most common infectious trigger in sHLH is Epstein-Barr virus (EBV-HLH) Current treatment protocols for EBV-HLH have a cure rate of approximately 75%, however, there are significant toxicities associated with these therapies We present two patients with EBV-HLH who experienced spontaneous resolution of their disease prior to the initiation of therapy, suggesting there may be a subgroup of patients with EBV-HLH who do well with conservative management and can avoid potentially toxic therapies Pediatr Blood Cancer 2010,55 754 756 (c) 2010 Wiley-Liss, Inc