Synthesis and Biological Activity of (Z) -n-(5-Benzylidene-4-oxo-2-substituted-phenylthiazolidin-3-yl)-5-((1, 3-dioxoisoindolin-2-yl)methyl)-2-hydroxybenzamide

被引：0
作者：
Patel, M. C. [1 ]
Dhameliya [1 ]
机构：
[1] PS Sci & HD Patel Arts Coll, Kadi, Gujarat, India
来源：
E-JOURNAL OF CHEMISTRY | 2010年 / 7卷 / 04期
关键词：
5-((1,3-Dioxoisoindolin-2-yl)methyl-2-hydroxybenzohydrazide; Thiazolidin; Antibacterial activity; ANTIMICROBIAL ACTIVITY; ANTICANCER; DISCOVERY; HYDRAZIDE; RESISTANT;
D O I：
10.1155/2010/586984
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
5-((1, 3-Dioxoisoindolin-2-yl)methyl-2-hydroxybenzohydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding N'-substituted-phenyl-5-((1,3-dioxoisoindolin-2-yl)methyl)-2-hydroxybenzohydrazide (2a-h) in good yields. Cyclocondensation of compounds (2a-h) with thioglycolic acid yields 5-((1,3-dioxoisoindolin-2-yl) methyl)-2-hydroxy-N-(4-oxo-2-substituted phenylthiazolidin-3-yl)benzamide (3a-h). These (3a-h) compounds were further reacted with benzaldehyde in the presence of sodium ethanolate affords, (Z) -N-(5-benzylidene-4-oxo-2-substituted phenylthiazolidin-3-yl)-5-((1,3-dioxoisoindolin-2-yl) methyl)-2-hydroxybenzamide(4a-h). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.
引用
收藏
页码：1484 / 1490
页数：7
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