Association of prenatal passive smoking and metabolic gene polymorphisms with child growth from birth to 3 years of age in the Hokkaido Birth Cohort Study on Environment and Children's Health

被引:6
作者
Braimoh, Titilola Serifat [1 ,2 ]
Kobayashi, Sumitaka [1 ,2 ]
Sata, Fumihiro [2 ,3 ]
Sasaki, Seiko [1 ]
Goudarzi, Houman [2 ,4 ]
Yila, Thamar Ayo [2 ]
Araki, Atsuko [2 ]
Miyashita, Chihiro [2 ]
Minakami, Hisanori [5 ]
Baba, Tsuyoshi [6 ]
Sengoku, Kazuo [7 ]
Kishi, Reiko [2 ]
机构
[1] Hokkaido Univ, Dept Publ Hlth Sci, Grad Sch Med, Kita Ku, North 15,West 7, Sapporo, Hokkaido 0600838, Japan
[2] Hokkaido Univ, Ctr Environm & Hlth Sci, Kita Ku, North 12,West 7, Sapporo, Hokkaido 0600812, Japan
[3] Chuo Univ, Ctr Hlth, Shinjuku Ku, 42-8 Ichigaya Hommura Cho, Tokyo 1628473, Japan
[4] Hokkaido Univ, Dept Resp Med, Grad Sch Med, Kita Ku, North 15,West 7, Sapporo, Hokkaido 0600838, Japan
[5] Hokkaido Univ, Dept Obstet & Gynecol, Grad Sch Med, Kita Ku, North 15,West 7, Sapporo, Hokkaido 0600838, Japan
[6] Sapporo Med Univ, Sch Med, Dept Obstet & Gynecol, Chuo Ku, South 1,West 17, Sapporo, Hokkaido 0608556, Japan
[7] Asahikawa Med Univ, Sch Med, Dept Obstet & Gynecol, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido 0788510, Japan
关键词
Prenatal passive smoking; Cytochrome P450 1A1 (CYP1A1); N-acetyltransferase 2 (NAT2); Child growth; Genetic polymorphism; FOR-GESTATIONAL-AGE; TOBACCO-SMOKE; MATERNAL SMOKING; TRANSPLACENTAL TRANSFER; RISK-FACTORS; PREGNANCY; EXPOSURE; NAT2; PROFILE; CONSUMPTION;
D O I
10.1016/j.scitotenv.2017.06.212
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Although the effects of prenatal passive smoking on birth weight have been reported, the effects of metabolic gene polymorphisms on passive smoking have not been studied. Therefore, we investigated the effects of maternal passive smoking and metabolic gene polymorphisms on child growth up to 3 years of age using cotinine as a biomarker. We included 1356 Japanese participants in a prospective cohort between 2003 and 2007 (cotinine levels at the third trimester <= 0.21 ng/mL and 0.22 to 11.48 ng/mL for non-passive and passive smokers, respectively), and measured child outcomes such as weight, length, head circumference, and Kaup index. Additionally, we analyzed cytochrome P450 1A1 (CYP1A1), epoxide hydrolase 1 (EPHX1), and two N-acetyltransferase 2 (NAT2) genotypes using real-time polymerase chain reaction methods. Associations were investigated using multiple regression models. Kaup index gain from birth up to 3 years of age was significantly smaller in children born to passive smokers than in those born to non-passive smokers (-0.34 kg/m(2); 95% confidence interval: -0.67, -0.01). Maternal CYP1A1 genotype was not associated with prenatal passive smoking and Kaup index gain, but was significantly associated with prenatal passive smoking and head circumference gain from birth up to 3 years of age (-0.75 cm; 95% confidence interval:-1.39, -0.12). Thus, this study suggests that prenatal passive smoking may have potent effects on postnatal growth frombirth up to 3 years of age. Moreover, children with maternal CYP1A1 genotype may be more susceptible to the effects of prenatal passive smoking. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码:995 / 1002
页数:8
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