Liposome antibody-ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration

被引：5

作者：

Accardo, Antonella ^{[1
,2
]}

Del Zoppo, Luisa ^{[1
,2
]}

Morelli, Giancarlo ^{[1
,2
]}

Condorelli, Daniele F. ^{[3
]}

Barresi, Vincenza ^{[3
]}

Musso, Nicolo ^{[3
]}

Spampinato, Giorgia ^{[3
]}

Bellia, Francesco ^{[4
]}

Tabbi, Giovanni ^{[4
]}

Rizzarelli, Enrico ^{[4
,5
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, CIRPeB, Via Mezzocannone 16, I-80134 Naples, Italy

[2] IBB CNR, Via Mezzocannone 16, I-80134 Naples, Italy

[3] Univ Catania, Sect Med Biochem, Dept Biomed & Biotechnol Sci, Via S Sofia 97, I-95125 Catania, Italy

[4] CNR, Inst Biostruct & Bioimaging, Via P Gaifami 18, I-95126 Catania, Italy

[5] Univ Catania, Dept Chem Sci, Viale A Doria 6, I-95125 Catania, Italy

来源：

MEDCHEMCOMM | 2016年 / 7卷 / 12期

关键词：

L-CARNOSINE; IMMUNOLIPOSOMES; GROWTH; IDENTIFICATION; INDUCTION; THERAPY;

D O I：

10.1039/c6md00461j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized. They represent a new class of antibody-drug conjugates because carnosine acts as an ionophore for Cu2+ or Zn2+, altering the metallostasis of cancer cells, leading to their death.

引用

收藏

页码：2364 / 2367

页数：4

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