Liposome antibody-ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration

被引：5
作者：
Accardo, Antonella [1 ,2 ]
Del Zoppo, Luisa [1 ,2 ]
Morelli, Giancarlo [1 ,2 ]
Condorelli, Daniele F. [3 ]
Barresi, Vincenza [3 ]
Musso, Nicolo [3 ]
Spampinato, Giorgia [3 ]
Bellia, Francesco [4 ]
Tabbi, Giovanni [4 ]
Rizzarelli, Enrico [4 ,5 ]
机构：
[1] Univ Naples Federico II, Dept Pharm, CIRPeB, Via Mezzocannone 16, I-80134 Naples, Italy
[2] IBB CNR, Via Mezzocannone 16, I-80134 Naples, Italy
[3] Univ Catania, Sect Med Biochem, Dept Biomed & Biotechnol Sci, Via S Sofia 97, I-95125 Catania, Italy
[4] CNR, Inst Biostruct & Bioimaging, Via P Gaifami 18, I-95126 Catania, Italy
[5] Univ Catania, Dept Chem Sci, Viale A Doria 6, I-95125 Catania, Italy
来源：
MEDCHEMCOMM | 2016年 / 7卷 / 12期
关键词：
L-CARNOSINE; IMMUNOLIPOSOMES; GROWTH; IDENTIFICATION; INDUCTION; THERAPY;
D O I：
10.1039/c6md00461j
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized. They represent a new class of antibody-drug conjugates because carnosine acts as an ionophore for Cu2+ or Zn2+, altering the metallostasis of cancer cells, leading to their death.
引用
收藏
页码：2364 / 2367
页数：4
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