Oral fluids that detect cardiovascular disease biomarkers

被引：30

作者：

Foley, Joseph D., III ^{[3
]}

Sneed, J. Darrell ^{[3
]}

Steinhubl, Steven R. ^{[5
]}

Kolasa, Justin ^{[2
]}

Ebersole, Jeffrey L. ^{[2
]}

Lin, Yushun ^{[4
]}

Kryscio, Richard J. ^{[4
]}

McDevitt, John T. ^{[6
]}

Campbell, Charles L. ^{[3
]}

Miller, Craig S. ^{[1
,2
]}

机构：

[1] Univ Kentucky, Coll Dent, Oral Med Sect, Dept Oral Hlth Practice, Lexington, KY 40536 USA

[2] Univ Kentucky, Coll Dent, Ctr Oral Hlth Res, Lexington, KY 40536 USA

[3] Univ Kentucky, Coll Med, Dept Internal Med, Div Cardiovasc Med, Lexington, KY 40536 USA

[4] Univ Kentucky, Dept Stat, Lexington, KY 40536 USA

[5] Geisinger Heart Inst, Div Cardiol, Danville, PA USA

[6] Rice Univ, Dept Chem, Houston, TX USA

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2012年 / 114卷 / 02期

基金：

美国国家卫生研究院;

关键词：

C-REACTIVE PROTEIN; SALIVARY BIOMARKERS;

D O I：

10.1016/j.oooo.2012.03.003

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. The aim of this study was to determine the utility of oral fluids for assessment of coronary and cardiovascular (CV) health. Study Design. Twenty-nine patients with preexisting CV disease underwent an invasive cardiac procedure (alcohol septal ablation or percutaneous coronary intervention) and provided unstimulated whole saliva (UWS), sublingual swabs (LS), gingival swabs (GS) and serum at 0, 8, 16, 24, and 48 hours. Concentrations of 13 relevant biomarkers were determined and correlated with levels in serum and the oral fluids. Results. Concentrations of the majority of biomarkers were higher in UWS than in LS and GS. Coronary and CV disease biomarkers in UWS correlated better with serum than with LS and GS based on group status and measures of time effect. Seven biomarkers demonstrated time effect changes consistent with serum biomarkers, including C-reactive protein and troponin I. Conclusions. Changes in serum biomarker profiles are reflected in oral fluids suggesting that oral fluid biomarkers could aid in the assessment of cardiac ischemia/necrosis. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:207-214)

引用

页码：207 / 214

页数：8

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