Structural basis for the slow-onset inhibition of the Mycobacterium tuberculosis enoyl-ACP reductase InhA

被引:0
|
作者
Lai, Cheng-Tsung [1 ]
Li, Huei-Jiun [2 ]
Liu, Nina [2 ]
Pan, Pan [2 ]
Tonge, Peter [1 ,2 ]
Simmerling, Carlos [1 ,2 ]
机构
[1] SUNY Stony Brook, Biochem & Struct Biol Program, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 242卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
215-COMP
引用
收藏
页数:1
相关论文
共 50 条
  • [1] A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA
    Li, Huei-Jiun
    Lai, Cheng-Tsung
    Pan, Pan
    Yu, Weixuan
    Liu, Nina
    Bommineni, Gopal R.
    Garcia-Diaz, Miguel
    Simmerling, Carlos
    Tonge, Peter J.
    ACS CHEMICAL BIOLOGY, 2014, 9 (04) : 986 - 993
  • [2] Rational modulation of inhibitor binding kinetics: Controlling the key interactions for the slow-onset inhibition of the mycobacterium tuberculosis enoyl-ACP reductase InhA
    Lai, Cheng-Tsung Eric
    Li, Huei-Jiun
    Pan, Pan
    Yu, Weixuan
    Liu, Nina
    Tonge, Peter J.
    Simmerling, Carlos
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [3] Slow-onset inhibition of 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis by an inorganic complex
    Oliveira, Jaim S.
    de Sousa, Eduardo H. S.
    de Souza, Osmar N.
    Moreira, Icaro S.
    Santos, Diogenes S.
    Basso, Luiz A.
    CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (19) : 2409 - 2424
  • [4] Evaluating the Impact of the Tyr158 pK a on the Mechanism and Inhibition of InhA, the Enoyl-ACP Reductase from Mycobacterium tuberculosis
    Davoodi, Shabnam
    Daryaee, Fereidoon
    Aramini, James M.
    Tolentino Collado, Jinnette
    He, YongLe
    Pollard, Alyssa C.
    Gil, Agnieszka A.
    Aramini, James M.
    Tonge, Peter J.
    BIOCHEMISTRY, 2023, 62 (12) : 1943 - 1952
  • [5] Unraveling the slow onset inhibition of InhA, the enoyl ACP reductase from mycobacterium tuberbulosis: Mechanism and inhibitor design
    Yu, Weixuan
    Li, Huei Jiun
    Eltschkner, Sandra
    Spagnuolo, Lauren
    Perryman, Alexander
    Chang, Andrew
    Kisker, Caroline
    Tonge, Peter
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 249
  • [6] Recent Advances and Structural Features of Enoyl-ACP Reductase Inhibitors of Mycobacterium tuberculosis
    Inturi, Bharathkumar
    Pujar, Gurubasavaraj V.
    Purohit, Madhusudhan N.
    ARCHIV DER PHARMAZIE, 2016, 349 (11) : 817 - 826
  • [7] Interacting AcpM with InhA, the enoyl-ACP reductase from M. tuberculosis
    Zhang, Xujie
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232 : 848 - 848
  • [8] Rational approach in the new antituberculosis agent design:: inhibitors of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis
    Andrade, Carolina Horta
    Mesquita Pasqualoto, Kerly Fernanda
    Zaim, Marcio Henrique
    Ferreira, Elizabeth Igne
    REVISTA BRASILEIRA DE CIENCIAS FARMACEUTICAS, 2008, 44 (02): : 167 - 179
  • [9] Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis
    Parikh, S
    Moynihan, DP
    Xiao, GP
    Tonge, PJ
    BIOCHEMISTRY, 1999, 38 (41) : 13623 - 13634
  • [10] Structural Basis for Inhibition of Enoyl-[Acyl Carrier Protein] Reductase (InhA) from Mycobacterium tuberculosis
    de Avila, Mauricio Boff
    Bitencourt-Ferreira, Gabriela
    de Azevedo Jr, Walter Filgueira
    CURRENT MEDICINAL CHEMISTRY, 2020, 27 (05) : 745 - 759