Glutathione Depletion Prevents Diet-Induced Obesity and Enhances Insulin Sensitivity

被引：37

作者：

Findeisen, Hannes M. ^{[1
]}

Gizard, Florence ^{[1
]}

Zhao, Yue ^{[1
,2
]}

Qing, Hua ^{[1
]}

Jones, Karrie L. ^{[1
]}

Cohn, Dianne ^{[1
]}

Heywood, Elizabeth B. ^{[1
]}

Bruemmer, Dennis ^{[1
,2
]}

机构：

[1] Univ Kentucky, Coll Med, Saha Cardiovasc Res Ctr, Lexington, KY 40506 USA

[2] Univ Kentucky, Coll Med, Grad Ctr Nutr Sci, Lexington, KY USA

来源：

OBESITY | 2011年 / 19卷 / 12期

基金：

美国国家卫生研究院;

关键词：

OXIDATIVE STRESS; RESISTANCE; MICE;

D O I：

10.1038/oby.2011.298

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Excessive accumulation of reactive oxygen species (ROS) in adipose tissue has been implicated in the development of insulin resistance and type 2 diabetes. However, emerging evidence suggests a physiologic role of ROS in cellular signaling and insulin sensitivity. In this study, we demonstrate that pharmacologic depletion of the antioxidant glutathione in mice prevents diet-induced obesity, increases energy expenditure and locomotor activity, and enhances insulin sensitivity. These observations support a beneficial role of ROS in glucose homeostasis and warrant further research to define the regulation of metabolism and energy balance by ROS.

引用

页码：2429 / 2432

页数：4

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