Synthesis and characterization of pH-sensitive crosslinked (NIPA-co-AAC) nanohydrogels copolymer

被引：13

作者：

Elsaeed, Shimaa M. ^{[1
]}

Farag, Reem K. ^{[1
]}

Maysour, Nermien S. ^{[1
]}

机构：

[1] Egyptian Petr Res Inst, Cairo 11727, Egypt

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2012年 / 124卷 / 03期

关键词：

nanohydrogels; N-isopropylacrylamide; inverse microemulsion polymerization; MICROPOROUS POLYMERIC MATERIALS; N-ISOPROPYLACRYLAMIDE; MICROEMULSION POLYMERIZATION; DRUG-DELIVERY; POLY(DIVINYLBENZENE) MICROSPHERES; THERMOSENSITIVE HYDROGELS; SOLUTE TRANSPORT; RESPONSIVE CORE; TEMPERATURE; RELEASE;

D O I：

10.1002/app.34912

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A thermoresponsive polymeric nanohydrogels has been synthesized by inverse microemulsion polymerization of N-isopropylacrylamide (NIPA) and acrylic acid (AAc) using Aerosol (AOT) as a surfactant, ethylene glycol dimethacrylate (EGDMA) as a crosslinker, and 2,2'-azobisisobutyronitrile (AIBN) as initiator. The effect of concentration of AIBN, EGDMA, and NIPA/AAc weight ratio was investigated. The lower critical solution temperature (LCST) of poly (NIPA-co-AAC) can be manipulated to be 40 degrees C and 45 degrees C which was correlated to amount of AAc that was copolymerized with NIPA. FTIR, 1H NMR, TEM, and DSC characterized the nanohydrogels. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

引用

页码：1947 / 1955

页数：9

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