Expression of vitellogenin in the testis and kidney of the spotted ray Torpedo marmorata exposed to 17β-estradiol

被引：10
作者：
Del Giudice, Giuseppina [1 ]
Prisco, Marina [1 ]
Agnese, Marisa [1 ]
Verderame, Mariailaria [1 ]
Limatola, Ermelinda [1 ]
Andreuccetti, Piero [1 ]
机构：
[1] Univ Naples Federico II, Dept Biol Sci, Evolutionary & Comparat Biol Div, I-80134 Naples, Italy
来源：
GENERAL AND COMPARATIVE ENDOCRINOLOGY | 2011年 / 174卷 / 03期
关键词：
Vitellogenin extra hepatic expression; Estrogens; Spotted ray; ESTROGEN-RESPONSIVE GENES; TROUT ONCORHYNCHUS-MYKISS; ZONA-RADIATA PROTEIN; RAINBOW-TROUT; SQUALUS-ACANTHIAS; ORYZIAS-LATIPES; SURFACE MUCUS; DANIO-RERIO; NONYLPHENOL; LIVER;
D O I：
10.1016/j.ygcen.2011.09.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In vertebrates, the liver was long thought to be the only site of vitellogenin (Vtg) production, but recent studies demonstrated that Vtg is also expressed in extrahepatic districts. The aim of this paper is to assess, by in situ hybridization and immunohistochemistry, the expression of Vtg in the testis and kidney of Torpedo marmorata exposed to 17 beta-estradiol (E-2). In treated samples vtg mRNA and Vtg were detected contemporaneously only in the testis; differently the kidney cells were positive to Vtg antibody, but negative to vtg mRNA. This is the first study to assess that male germ cells, after an exposure to E-2, synthesize Vtg in a stage-dependent manner. The presence of Vtg and the modifications observed in the kidney after E-2 treatment are discussed. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：318 / 325
页数：8
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