An appraisal of vascular endothelial growth factor (VEGF): the dynamic molecule of wound healing and its current clinical applications

被引：43

作者：

Goswami, Aakansha Giri ^{[1
]}

Basu, Somprakas ^{[1
]}

Huda, Farhanul ^{[1
]}

Pant, Jayanti ^{[2
]}

Ghosh Kar, Amrita ^{[3
]}

Banerjee, Tuhina ^{[4
]}

Shukla, Vijay Kumar ^{[5
]}

机构：

[1] All India Inst Med Sci, Dept Gen Surg, Rishikesh 249203, India

[2] All India Inst Med Sci, Dept Physiol, Rishikesh, India

[3] Banaras Hindu Univ, Inst Med Sci, Dept Pathol, Varanasi, Uttar Pradesh, India

[4] Banaras Hindu Univ, Inst Med Sci, Dept Microbiol, Varanasi, Uttar Pradesh, India

[5] Banaras Hindu Univ, Inst Med Sci, Dept Gen Surg, Varanasi, Uttar Pradesh, India

来源：

GROWTH FACTORS | 2022年 / 40卷 / 3-4期

关键词：

Vascular endothelial growth factor; wound healing; angiogenesis; diabetic ulcer; venous ulcer; peripheral arterial disease; PERIPHERAL ARTERIAL-DISEASE; INTRAMUSCULAR GENE-TRANSFER; PERMEABILITY FACTOR; PLASMINOGEN-ACTIVATOR; PROGENITOR CELLS; FACTOR RECEPTOR-1; FACTOR EXPRESSION; PRESSURE ULCER; NITRIC-OXIDE; DOUBLE-BLIND;

D O I：

10.1080/08977194.2022.2074843

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Angiogenesis is a critical step of wound healing, and its failure leads to chronic wounds. The idea of restoring blood flow to the damaged tissues by promoting neo-angiogenesis is lucrative and has been researched extensively. Vascular endothelial growth factor (VEGF), a key dynamic molecule of angiogenesis has been investigated for its functions. In this review, we aim to appraise its biology, the comprehensive role of this dynamic molecule in the wound healing process, and how this knowledge has been translated in clinical application in various types of wounds. Although, most laboratory research on the use of VEGF is promising, its clinical applications have not met great expectations. We discuss various lacunae that might exist in making its clinical application unsuccessful for commercial use, and provide insight to the foundation for future research.

引用

页码：73 / 88

页数：16

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