Peptide-based delivery of therapeutics in cancer treatment

被引：51

作者：

Samec, Timothy ^{[1
]}

Boulos, Jessica ^{[1
]}

Gilmore, Serena ^{[1
]}

Hazelton, Anthony ^{[1
]}

Alexander-Bryant, Angela ^{[1
,2
]}

机构：

[1] Clemson Univ, Dept Bioengn, Nanobiotechnol Lab, Clemson, SC USA

[2] Rhodes Engn Res Ctr, 301 Engn Serv Dr, Clemson, SC 29631 USA

来源：

MATERIALS TODAY BIO | 2022年 / 14卷

基金：

美国国家科学基金会; 芬兰科学院;

关键词：

Peptide delivery; Nanoparticle conjugation; Gene therapy; Drug therapy; Cancer; CELL-PENETRATING PEPTIDE; RECEPTOR-BINDING PEPTIDES; FUSION PEPTIDE; DRUG-DELIVERY; ENDOSOMAL ESCAPE; PHAGE DISPLAY; IN-VITRO; MEMBRANE-FUSION; SIRNA DELIVERY; OVARIAN-CANCER;

D O I：

10.1016/j.mtbio.2022.100248

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Current delivery strategies for cancer therapeutics commonly cause significant systemic side effects due to required high doses of therapeutic, inefficient cellular uptake of drug, and poor cell selectivity. Peptide-based delivery systems have shown the ability to alleviate these issues and can significantly enhance therapeutic loading, delivery, and cancer targetability. Peptide systems can be tailor-made for specific cancer applications. This review describes three peptide classes, targeting, cell penetrating, and fusogenic peptides, as stand-alone nanoparticle systems, conjugations to nanoparticle systems, or as the therapeutic modality. Peptide nanoparticle design, characteristics, and applications are discussed as well as peptide applications in the clinical space.

引用

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