Peptide-based delivery of therapeutics in cancer treatment

被引：51

作者：

Samec, Timothy ^{[1
]}

Boulos, Jessica ^{[1
]}

Gilmore, Serena ^{[1
]}

Hazelton, Anthony ^{[1
]}

Alexander-Bryant, Angela ^{[1
,2
]}

机构：

[1] Clemson Univ, Dept Bioengn, Nanobiotechnol Lab, Clemson, SC USA

[2] Rhodes Engn Res Ctr, 301 Engn Serv Dr, Clemson, SC 29631 USA

来源：

MATERIALS TODAY BIO | 2022年 / 14卷

基金：

美国国家科学基金会; 芬兰科学院;

关键词：

Peptide delivery; Nanoparticle conjugation; Gene therapy; Drug therapy; Cancer; CELL-PENETRATING PEPTIDE; RECEPTOR-BINDING PEPTIDES; FUSION PEPTIDE; DRUG-DELIVERY; ENDOSOMAL ESCAPE; PHAGE DISPLAY; IN-VITRO; MEMBRANE-FUSION; SIRNA DELIVERY; OVARIAN-CANCER;

D O I：

10.1016/j.mtbio.2022.100248

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Current delivery strategies for cancer therapeutics commonly cause significant systemic side effects due to required high doses of therapeutic, inefficient cellular uptake of drug, and poor cell selectivity. Peptide-based delivery systems have shown the ability to alleviate these issues and can significantly enhance therapeutic loading, delivery, and cancer targetability. Peptide systems can be tailor-made for specific cancer applications. This review describes three peptide classes, targeting, cell penetrating, and fusogenic peptides, as stand-alone nanoparticle systems, conjugations to nanoparticle systems, or as the therapeutic modality. Peptide nanoparticle design, characteristics, and applications are discussed as well as peptide applications in the clinical space.

引用

页数：17

共 209 条

[1] Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs [J].

Accardo, Antonella ;

Aloj, Luigi ;

Aurilio, Michela ;

Morelli, Giancarlo ;

Tesauro, Diego .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 9 :1537-1557

[2] Therapeutic cancer targeting peptides [J].

Aina, OH ;

Sroka, TC ;

Chen, ML ;

Lam, KS .

BIOPOLYMERS, 2002, 66 (03) :184-199

[3] From combinatorial chemistry to cancer-targeting peptides [J].

Aina, Olulanu H. ;

Liu, Ruiwu ;

Sutcliffe, Julie L. ;

Marik, Jan ;

Pan, Chong-Xian ;

Lam, Kit S. .

MOLECULAR PHARMACEUTICS, 2007, 4 (05) :631-651

[4] Liposome: classification, preparation, and applications [J].

Akbarzadeh, Abolfazl ;

Rezaei-Sadabady, Rogaie ;

Davaran, Soodabeh ;

Joo, Sang Woo ;

Zarghami, Nosratollah ;

Hanifehpour, Younes ;

Samiei, Mohammad ;

Kouhi, Mohammad ;

Nejati-Koshki, Kazem .

NANOSCALE RESEARCH LETTERS, 2013, 8

[5] Lipid-Peptide Vesicle Nanoscale Hybrids for Triggered Drug Release by Mild Hyperthermia in Vitro and in Vivo [J].

Al-Ahmady, Zahraa S. ;

Al-Jamal, Wafa' T. ;

Bossche, Jeroen V. ;

Bui, Tam T. ;

Drake, Alex F. ;

Mason, A. James ;

Kostarelos, Kostas .

ACS NANO, 2012, 6 (10) :9335-9346

[6] Therapeutic potential of a cell penetrating peptide (CPP, NP1) mediated siRNA delivery: Evidence in 3D spheroids of colon cancer cells [J].

Al-Husaini, Khalsa ;

Elkamel, Erij ;

Han, Xiaoxia ;

Chen, Pu .

CANADIAN JOURNAL OF CHEMICAL ENGINEERING, 2020, 98 (06) :1240-1254

[7] Fusogenic-oligoarginine peptide-mediated silencing of the CIP2A oncogene suppresses oral cancer tumor growth in vivo [J].

Alexander-Bryant, Angela A. ;

Dumitriu, Anca ;

Attaway, Christopher C. ;

Yu, Hong ;

Jakymiw, Andrew .

JOURNAL OF CONTROLLED RELEASE, 2015, 218 :72-81

[8] Bioengineering Strategies for Designing Targeted Cancer Therapies [J].

Alexander-Bryant, Angela A. ;

Vanden Berg-Foels, Wendy S. ;

Wen, Xuejun .

ADVANCES IN CANCER RESEARCH, VOL 118, 2013, 118 :1-59

[9] Liposomal drug delivery systems: From concept to clinical applications [J].

Allen, Theresa M. ;

Cullis, Pieter R. .

ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (01) :36-48

[10]

[Anonymous], 2001, Immunobiol Immune Syst Heal Dis, P1

← 1 2 3 4 5 6 7 8 9 10 →