Oligonucleotide stabilized silver nanoclusters as fluorescence probe for drug-DNA interaction investigation

被引：50

作者：

Yuan, Jipei ^{[1
]}

Guo, Weiwei ^{[1
]}

Wang, Erkang ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China

来源：

ANALYTICA CHIMICA ACTA | 2011年 / 706卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Fluorescence; Silver nanoclusters; Quenching; Drug-DNA interaction; SEQUENCE SPECIFICITY; AG NANOCLUSTERS; HOECHST; 33258; BINDING; QUINACRINE; DAUNOMYCIN; DAUNORUBICIN; MITOXANTRONE; AFM;

D O I：

10.1016/j.aca.2011.08.043

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this work, oligonucleotide stabilized silver nanoclusters as novel fluorescent probes were successfully utilized for the drug-DNA interaction study. Silver nanoclusters were proved to be sensitive probes for the drugs investigated (including of two kinds of intercalators, daunorubicin and quinacrine, as well as a non-intercalating binder bisBenzimide H 33258), as the detection limits at 10(-8) mol L-1 level of studied drugs can be achieved. The interactions of drugs and calf thymus DNA were investigated using non-linear fit analysis, and the binding constants as well as binding site sizes were obtained. As biocompatible materials, silver nanoclusters are promising in the chemical especially biochemical analysis fields. (C) 2011 Elsevier B.V. All rights reserved.

引用

收藏

页码：338 / 342

页数：5

相关论文

共 55 条

[1] Voltammetric studies of the interaction of quinacrine with DNA [J].

Aslanoglu, M ;

Ayne, G .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2004, 380 (04) :658-663

[2] Binding of Hoechst 33258 and its Derivatives to DNA [J].

Bazhulina, N. P. ;

Nikitin, A. M. ;

Rodin, S. A. ;

Surovaya, A. N. ;

Kravatsky, Yu. V. ;

Pismensky, V. F. ;

Archipova, V. S. ;

Martin, R. ;

Gursky, G. V. .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2009, 26 (06) :701-718

[3] The excited states quenching of phenothiazine dyes by p-benzoquinones in polar solvents [J].

Bertolotti, SG ;

Previtali, CM .

DYES AND PIGMENTS, 1999, 41 (1-2) :55-61

[4] Base-sequence specificity of Hoechst 33258 and DAPI binding to five (A/T)4 DNA sites with kinetic evidence for more than one high-affinity Hoechst 33258-AATT complex [J].

Breusegem, SY ;

Clegg, RM ;

Loontiens, FG .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 315 (05) :1049-1061

[5] Electron shuttling across the interface of CdSe nanoparticles monitored by femtosecond laser spectroscopy [J].

Burda, C ;

Green, TC ;

Link, S ;

El-Sayed, MA .

JOURNAL OF PHYSICAL CHEMISTRY B, 1999, 103 (11) :1783-1788

[6] ANALYSIS OF BINDING OF DAUNORUBICIN AND DOXORUBICIN TO DNA USING COMPUTERIZED CURVE-FITTING PROCEDURES [J].

BYRN, SR ;

DOLCH, GD .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (05) :688-693

[7] SITE AND SEQUENCE SPECIFICITY OF THE DAUNOMYCIN DNA INTERACTION [J].

CHAIRES, JB ;

FOX, KR ;

HERRERA, JE ;

BRITT, M ;

WARING, MJ .

BIOCHEMISTRY, 1987, 26 (25) :8227-8236

[8] BIOPHYSICAL CHEMISTRY OF THE DAUNOMYCIN-DNA INTERACTION [J].

CHAIRES, JB .

BIOPHYSICAL CHEMISTRY, 1990, 35 (2-3) :191-202

[9] A THEORETICAL INVESTIGATION ON THE SEQUENCE SELECTIVE BINDING OF MITOXANTRONE TO DOUBLE-STRANDED TETRANUCLEOTIDES [J].

CHEN, KX ;

GRESH, N ;

PULLMAN, B .

NUCLEIC ACIDS RESEARCH, 1986, 14 (09) :3799-3812

[10] Electrochemical and AFM evaluation of hazard compounds-DNA interaction [J].

Chiorcea-Paquim, A. -M. ;

Corduneanu, O. ;

Oliveira, S. C. B. ;

Diculescu, V. C. ;

Oliveira-Brett, A. M. .

ELECTROCHIMICA ACTA, 2009, 54 (07) :1978-1985

← 1 2 3 4 5 6 →