Novel cytotoxic diterpenes from the stem of Dysoxylum kuskusense

被引：20

作者：

Fujioka, T

Yamamoto, M

Kashiwada, Y

Fujii, H

Mihashi, K

Ikeshiro, Y

Chen, IS

Lee, KH ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka 8140180, Japan

[2] Niigata Coll Pharm, Niigata 9502081, Japan

[3] Kaohsiung Med Coll, Nat Prod Res Ctr, Kaohsiung, Taiwan

[4] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(98)00630-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three novel diterpenes, dysokusones A (1), B (2), and C (3), were isolated from the stem of Dysoxylum kuskusense as cytotoxic substances. The structures were established by spectroscopic examinations. Compounds 1, 2, and 3 were cytotoxic toward HL-60(TB) cells with EC50 values of 2.25, 6.35, and 2.37 mu M, respectively. Compound 1 also displayed cytotoxicity against K-562 and NCI-H522 cells with EC50 values of 5.04 and 4.80 mu M, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3479 / 3482

页数：4

共 8 条

[1] ODONTIN AND ODONTICIN, 2 NEW EUDESMANE SESQUITERPENES FROM PLUCHEA-ARGUTA [J].