The concentration and health risk of potentially toxic elements (PTEs) in the breast milk of mothers: a systematic review and meta-analysis

Aim: Breast milk is the best source of nutrition for a newborn during the first six months of his or her life. However there is a possibility that breast milk may contain pollutants such as metals. The current meta-analytic study assessed the concentration of potentially toxic elements (PTEs), including lead (Pb), cadmium (Cd), arsenic (As), Iron (Fe), Zinc (Zn), copper (Cu), and nickel (Ni), in mothers' milk. Method: The literature studies regarding the concentrations of PTEs in the breast milk of mothers were collected from international databases such as PubMed, Scopus, Web of Science, and Embase. Afterward, the Total Target Hazard Quotient (TTHQ) by Monte Carlo Simulation (MCS) model was used to assess the non-carcinogenic risk. Results and discussion: According to 42 of the 836 retrieved articles, the PTE concentrations in mother's milk were as follows: Cu (1.84 mg/kg) > Zn (1.80 mg/kg) > Fe (1.03 mg/kg) > Ni (0.60 mg/kg) > Pb (0.10 mg/kg) > As (0.15 mg/kg) asymptotic to Cd (0.15 mg/kg). Based on the containment type, the highest concentrations of As (2.80 mg/kg), Cd (0.07 mg/kg), and Pb (2.68 mg/kg) were related to Western Pacific Region (WPRO), European Region (EURO), and WPRO, respectively. In addition, for trace elements, Eastern Mediterranean Region (EMRO) was the region with the highest concentrations of Cu (3.56 mg/kg), Fe (2.78 mg/kg), Ni (3.13 mg/kg), and Zn (5.58 mg/kg) were related to Lastly, the non-carcinogenic risk assessment of the PTEs in breast milk indicated different risk patterns in various countries, and the calculated TTHQ level in infants was below 1. Conclusion: Overall, human breast milk was generally safe for infants to consume and poses no risks to their health.