Construction of substituted N-hydroxyindoles:: Synthesis of a nocathiacin I model system

被引：49

作者：

Nicolaou, KC

Lee, SH

Estrada, AA

Zak, M

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 24期

关键词：

indoles; natural products; nitrones; nucleophilic addition; synthetic methods;

D O I：

10.1002/anie.200500724

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Generation (1→2) and trapping (2→3) of the fleeting α,β-unsaturated nitrone system 2 leads to the rare, biologically important N-hydroxyindole 3 in synthetically useful yields. This structural motif is found within the molecule of the antibiotic nocathiacin I. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：3736 / 3740

页数：5

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