Accessing 1,3-Dienes via Palladium-Catalyzed Allylic Alkylation of Pronucleophiles with Skipped Enynes

被引：32

作者：

Gao, Shang

Liu, Hao

Yang, Chi

Fu, Zhiyuan

Yao, Hequan ^{[1
]}

Lin, Aijun ^{[1
]}

机构：

[1] China Pharmaceut Univ, SKLNM, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 18期

基金：

中国国家自然科学基金;

关键词：

INTERNAL ALKYNES; C-C; DIENES; ZAMPANOLIDE; CYCLIZATION; ALLYLATION; 1,4-DIENES; COMPLEXES; BUTADIENE; ACRYLATES;

D O I：

10.1021/acs.orglett.7b01960

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented palladium-catalyzed allylic alkylation of pronucleophiles with unactivated skipped enynes has been developed. This method provides a straightforward access to a-wide array of 1,3-dienes without the need to preinstall leaving groups or employ extra oxidants. The reaction exhibited high atom, economy, good functional group tolerance, excellent regioselectivities, and scalability. With D2O as cosolvent, deuterium could be incorporated in high efficiency.

引用

页码：4710 / 4713

页数：4

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