Alpha-1-syntrophin protein is differentially expressed in human cancers

被引：19
作者：
Bhat, Hina F. [1 ]
Baba, Rafia A. [1 ]
Bashir, Muneesa [1 ]
Saeed, Safder [1 ]
Kirmani, Deeba [2 ]
Wani, Mudassir M. [3 ]
Wani, Nisar A. [3 ]
Wani, Khursheed A. [4 ]
Khanday, Firdous A. [1 ]
机构：
[1] Univ Kashmir, Dept Biotechnol, Srinagar 190006, Jammu & Kashmir, India
[2] Univ Kashmir, Dept Biochem, Srinagar 190006, Jammu & Kashmir, India
[3] SMHS Hosp, Govt Med Coll, Dept Surg, Srinagar, Jammu & Kashmir, India
[4] Sheri Kashmir Inst Med Sci, Dept Surg, Soura, Jammu & Kashmir, India
来源：
BIOMARKERS | 2011年 / 16卷 / 01期
关键词：
Alpha-1-syntrophin; signal transduction; esophageal squamous cell carcinoma; adenocarcinoma; breast cancer; DYSTROPHIN-ASSOCIATED PROTEIN; COLORECTAL-CANCER; TUMOR-SUPPRESSOR; PDZ DOMAIN; SYNTROPHIN; JUNCTION; P66SHC; RAC1; PHOSPHORYLATION; GLYCOPROTEIN;
D O I：
10.3109/1354750X.2010.522731
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We studied the expression of alpha 1-syntrophin (SNTA1) protein in histologically confirmed esophageal, stomach, lung, colon, rectal and breast cancerous tissue samples. Our results suggest a significant decrease in the expression level of SNTA1 protein in both esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) compared with their respective controls while a significant increase in expression of SNTA1 protein compared with the normal tissue was observed in breast carcinoma samples. No significant difference in expression of SNTA1 protein was observed in stomach, lung, colon and rectal cancers. Our results suggest that SNTA1 has a role in carcinogenesis and could possibly be used as a novel diagnostic or prognostic marker in esophageal and breast cancers.
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页码：31 / 36
页数：6
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