Reactive oxygen species and vascular biology: implications in human hypertension

被引:340
作者
Touyz, Rhian M. [1 ]
Briones, Ana M. [1 ]
机构
[1] Univ Ottawa, Kidney Res Ctr, Ottawa Hlth Res Inst, Ottawa, ON K1H 8M5, Canada
基金
加拿大健康研究院;
关键词
antioxidant; blood pressure; inflammation; Nox; superoxide; vascular remodeling; SMOOTH-MUSCLE-CELLS; EXTRACELLULAR-SUPEROXIDE DISMUTASE; RENIN-ANGIOTENSIN SYSTEM; NITRIC-OXIDE SYNTHASE; GP91PHOX-CONTAINING NADPH OXIDASE; HYDROGEN-PEROXIDE PRODUCTION; CHRONIC KIDNEY-DISEASE; SLOW PRESSOR-RESPONSE; OXIDATIVE STRESS; BLOOD-PRESSURE;
D O I
10.1038/hr.2010.201
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Increased vascular production of reactive oxygen species (ROS; termed oxidative stress) has been implicated in various chronic diseases, including hypertension. Oxidative stress is both a cause and a consequence of hypertension. Although oxidative injury may not be the sole etiology, it amplifies blood pressure elevation in the presence of other pro-hypertensive factors. Oxidative stress is a multisystem phenomenon in hypertension and involves the heart, kidneys, nervous system, vessels and possibly the immune system. Compelling experimental and clinical evidence indicates the importance of the vasculature in the pathophysiology of hypertension and as such much emphasis has been placed on the (patho) biology of ROS in the vascular system. A major source for cardiovascular, renal and neural ROS is a family of non-phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox), including the prototypic Nox2 homolog-based NADPH oxidase, as well as other Noxes, such as Nox1 and Nox4. Nox-derived ROS is important in regulating endothelial function and vascular tone. Oxidative stress is implicated in endothelial dysfunction, inflammation, hypertrophy, apoptosis, migration, fibrosis, angiogenesis and rarefaction, important processes involved in vascular remodeling in hypertension. Despite a plethora of data implicating oxidative stress as a causative factor in experimental hypertension, findings in human hypertension are less conclusive. This review highlights the importance of ROS in vascular biology and focuses on the potential role of oxidative stress in human hypertension. Hypertension Research (2011) 34, 5-14; doi: 10.1038/hr.2010.201; published online 28 October 2010
引用
收藏
页码:5 / 14
页数:10
相关论文
共 188 条
  • [1] Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice
    Adlam, D.
    Bendall, J. K.
    De Bono, J. P.
    Alp, N. J.
    Khoo, J.
    Nicoli, T.
    Yokoyama, M.
    Kawashima, S.
    Channon, K. M.
    [J]. EXPERIMENTAL PHYSIOLOGY, 2007, 92 (01) : 119 - 126
  • [2] Role of Proinflammatory Cytokines and Redox Homeostasis in Exercise-Induced Delayed Progression of Hypertension in Spontaneously Hypertensive Rats
    Agarwal, Deepmala
    Haque, Masudul
    Sriramula, Srinivas
    Mariappan, Nithya
    Pariaut, Romain
    Francis, Joseph
    [J]. HYPERTENSION, 2009, 54 (06) : 1393 - U161
  • [3] Increased expression of gp91phox homologues of NAD(P)H oxidase in the aortic media during chronic hypertension: Involvement of the renin-angiotensin system
    Akasaki, Takashi
    Ohya, Yusuke
    Kuroda, Junya
    Eto, Kimika
    Abe, Isao
    Sumimoto, Hideki
    Iida, Mitsuo
    [J]. HYPERTENSION RESEARCH, 2006, 29 (10) : 813 - 820
  • [4] Noxal is a central component of the smooth muscle NADPH oxidase in mice
    Ambasta, Rashmi K.
    Schreiber, Judith G.
    Janiszewski, Mariano
    Busse, Rudi
    Brandes, Ralf P.
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 (02) : 193 - 201
  • [5] NADPH oxidase
    Babior, BM
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (01) : 42 - 47
  • [6] Effect of Exercise on Cardiac Tissue Oxidative and Inflammatory Mediators in Chronic Kidney Disease
    Bai, Y.
    Sigala, W.
    Adams, G. R.
    Vaziri, N. D.
    [J]. AMERICAN JOURNAL OF NEPHROLOGY, 2009, 29 (03) : 213 - 221
  • [7] NOX5 variants are functionally active in endothelial cells
    BelAiba, Rachida S.
    Djordjevic, Talija
    Petry, Andreas
    Diemer, Kerstin
    Bonello, Steve
    Banfi, Botond
    Hess, John
    Pogrebniak, Alexej
    Bickel, Christian
    Goerlach, Agnes
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2007, 42 (04) : 446 - 459
  • [8] Berk Bradford C, 2007, Trans Am Clin Climatol Assoc, V118, P209
  • [9] Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II - Role in mesangial cell hypertrophy and fibronectin expression
    Block, Karen
    Eid, Assaad
    Griendling, Kathy K.
    Lee, Duck-Yoon
    Wittrant, Yohann
    Gorin, Yves
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (35) : 24061 - 24076
  • [10] Regulation of the phagocyte NADPH oxidase by Rac GTPase
    Bokoch, Gary M.
    Zhao, Tieming
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2006, 8 (9-10) : 1533 - 1548