Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research

被引：54

作者：

Li, Rui ^{[1
]}

Lin, Qiu-Xia ^{[1
]}

Liang, Xue-Zhen ^{[2
]}

Liu, Guang-Bo ^{[1
]}

Tang, He ^{[1
]}

Wang, Yu ^{[1
]}

Lu, Shi-Bi ^{[1
]}

Peng, Jiang ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Regenerat Med Orthoped, Inst Orthoped, Key Lab Musculoskeletal Trauma & War Injuries, Beijing 100853, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Clin Med Sch 1, Jinan 250355, Shandong, Peoples R China

来源：

STEM CELL RESEARCH & THERAPY | 2018年 / 9卷

基金：

中国国家自然科学基金;

关键词：

Hip; Osteonecrosis; Cell therapy; Mesenchymal stem cells; MESENCHYMAL STROMAL CELLS; CORTICOSTEROID-INDUCED OSTEONECROSIS; EARLY-STAGE OSTEONECROSIS; MARROW MONONUCLEAR-CELLS; BONE-MARROW; AVASCULAR NECROSIS; OSTEOGENIC DIFFERENTIATION; NONTRAUMATIC OSTEONECROSIS; CORE DECOMPRESSION; RISK-FACTORS;

D O I：

10.1186/s13287-018-1018-7

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Osteonecrosis of the femoral head (ONFH) is a refractory disease that is associated with collapse of the femoral head, with a risk of hip arthroplasty in younger populations. Thus, there has been an increased focus on early interventions for ONFH that aim to preserve the native articulation. Stem cell therapy is a promising treatment, and an increasing number of recent studies have focused on this topic. Many clinical studies have reported positive outcomes of stem cell therapy for the treatment of ONFH. To improve the therapeutic effects of this approach, many related basic research studies have also been performed. However, some issues must be further explored, such as the appropriate patient selection procedure, the optimal stem cell selection protocol, the ideal injection number, and the safety of stem cell therapy. The purpose of this review is to summarize the available clinical studies and basic research related to stem cell therapy for ONFH.

引用

页数：11

共 88 条

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