Synthesis and optimization of experimental variables of a hybrid organic-inorganic compound

A multivariate study of the experimental parameters used in hydrothermal techniques (temperature, time, pH, relationship among reagents) was performed, and applied to the synthesis of a copper hybrid compound, [Cu(biqui)(H2PO4)(2)] In this way it was possible to rationalize the crystal yield and to find the best conditions to obtain the highest crystal production. The optimization was carried out through the Response Surface Method (RSM). The optimal values were determined over the response surface by the SIMPLEX method. These values were pH = 2.5, temperature = 123 degrees C, time = 3.32 days and Cu(NO3)(2) mass = 0.354 g. With these values the predicted crystal mass is 0.0376 +/- 0.0082 g, considering the 95% of confidence interval.