Determination of Pancuronium and Its Impurities in Pharmaceutical Preparation by LC with Charged Aerosol Detection

被引：8

作者：

Blazewicz, Agata ^{[1
]}

Fijalek, Zbigniew ^{[1
,2
]}

Sarna, Katarzyna ^{[1
]}

Warowna-Grzeskiewicz, Malgorzata ^{[1
,3
]}

机构：

[1] Natl Med Inst, Dept Pharmaceut Chem, PL-00725 Warsaw, Poland

[2] Warsaw Med Univ, Dept Drug Anal, PL-02097 Warsaw, Poland

[3] Warsaw Med Univ, Dept Inorgan & Analyt Chem, PL-02097 Warsaw, Poland

来源：

CHROMATOGRAPHIA | 2010年 / 72卷 / 1-2期

关键词：

Column liquid chromatography; Charged aerosol detection; Corona CAD; Muscle relaxants; Pancuronium; PERFORMANCE LIQUID-CHROMATOGRAPHY; NEUROMUSCULAR BLOCKING-AGENTS; HPLC; ATRACURIUM; VALIDATION; INJECTIONS; BROMIDE; SUICIDE; DEATHS;

D O I：

10.1365/s10337-010-1623-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel, sensitive and simple liquid chromatography method with charged aerosol detection (LC-CAD) for the simultaneous assay determination of pancuronium and its impurities (dacuronium and vecuronium) has been developed. The limit of quantitation for vecuronium and dacuronium was 1.64 and 3.42 mu g mL(-1), respectively. The elaborated method was validated for linearity, precision and accuracy. This LC-CAD method is expected to have potential application in routine analysis of pancuronium in substance and in pharmaceutical preparations. All impurities were confirmed using time-of-flight mass spectrometry with electrospray ionization.

引用

页码：183 / 186

页数：4

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