Ribozyme catalysis revisited: Is water involved?

被引：41
作者：
Walter, Nils G. [1 ]
机构：
[1] Univ Michigan, Single Mol Anal Grp, Dept Chem, Ann Arbor, MI 48019 USA
来源：
MOLECULAR CELL | 2007年 / 28卷 / 06期
关键词：
D O I：
10.1016/j.molcel.2007.12.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Enzymatic catalysis by RNA was discovered 25 years ago, yet mechanistic insights are emerging only slowly. Thought to be metalloenzymes at first, some ribozymes proved more versatile than anticipated when shown to utilize their own functional groups for catalysis. Recent evidence suggests that some may also judiciously place structural water molecules to shuttle protons in acid-base catalyzed reactions.
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收藏
页码：923 / 929
页数：7
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