The IGF axis and placental function

被引：132
作者：
Forbes, Karen [1 ]
Westwood, Melissa [1 ]
机构：
[1] Univ Manchester, St Marys Hosp, Maternal Fetal Hlth Res Grp, Manchester M13 0JH, Lancs, England
来源：
HORMONE RESEARCH | 2008年 / 69卷 / 03期
关键词：
placenta; proliferation; differentiation; migration; apoptosis; insulin-like growth factor; insulin-like growth factor binding protein; PI3K; mitogen-activated protein kinase;
D O I：
10.1159/000112585
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
It is well known that the insulin-like growth factor (IGF) axis is an important regulator of foetal growth and in recent years, it has been suggested that the ligands IGF-I and IGF-II may, in part, mediate this effect by promoting proper placental development and function. In other tissues, IGF effects on metabolism, proliferation and differentiation are primarily mediated via IGF binding protein-regulated interaction of IGFs with the type 1 IGF receptor and therefore here, we review the placental expression and postulated role, of each of the IGF axis components and discuss the cellular mechanisms through which these effects are exerted. Copyright (c) 2008 S. Karger AG, Basel.
引用
收藏
页码：129 / 137
页数：9
相关论文
共 71 条
[1]  
Abu-Amero SN, 1998, MOL REPROD DEV, V49, P229, DOI 10.1002/(SICI)1098-2795(199803)49:3<229::AID-MRD2>3.0.CO
[2]  
2-Q
[3]   Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway [J].
Ain, R ;
Canham, LN ;
Soares, MJ .
JOURNAL OF ENDOCRINOLOGY, 2005, 185 (02) :253-263
[4]   Growth factor-extracellular matrix synergy in the control of trophoblast invasion [J].
Aplin, JD ;
Lacey, H ;
Haigh, T ;
Jones, CJP ;
Chen, CP ;
Westwood, M .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2000, 28 :199-202
[5]  
BAKER J, 1993, CELL, V75, P73, DOI 10.1016/0092-8674(93)90680-O
[6]   POTENTIATION OF EPIDERMAL GROWTH FACTOR-INDUCED DIFFERENTIATION OF CULTURED HUMAN PLACENTAL CELLS BY INSULIN-LIKE GROWTH FACTOR-I [J].
BHAUMICK, B ;
GEORGE, D ;
BALA, RM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 74 (05) :1005-1011
[7]   The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development [J].
Christie, GR ;
Williams, DJ ;
MacIsaac, F ;
Dickinson, RJ ;
Rosewell, I ;
Keyse, SM .
MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (18) :8323-8333
[8]   Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems [J].
Constância, M ;
Angiolini, E ;
Sandovici, I ;
Smith, P ;
Smith, R ;
Kelsey, G ;
Dean, W ;
Ferguson-Smith, A ;
Sibley, CP ;
Reik, W ;
Fowden, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (52) :19219-19224
[9]   Placental-specific IGF-II is a major modulator of placental and fetal growth [J].
Constância, M ;
Hemberger, M ;
Hughes, J ;
Dean, W ;
Ferguson-Smith, A ;
Fundele, R ;
Stewart, F ;
Kelsey, G ;
Fowden, A ;
Sibley, C ;
Reik, W .
NATURE, 2002, 417 (6892) :945-948
[10]   Matrix metalloprotease-3 and-9 proteolyze insulin-like growth factor-binding protein-1 [J].
Coppock, HA ;
White, A ;
Aplin, JD ;
Westwood, M .
BIOLOGY OF REPRODUCTION, 2004, 71 (02) :438-443
12345678