Muscarinic dependence of nucleus basalis induced conditioned receptive field plasticity

被引：72
作者：
Miasnikov, AA
McLin, D
Weinberger, NM [1 ]
机构：
[1] Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA
来源：
NEUROREPORT | 2001年 / 12卷 / 07期
关键词：
atropine; cholinergic system; learning; memory;
D O I：
10.1097/00001756-200105250-00047
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Receptive field (RF) plasticity in primary auditory cortex of adult animals, specifically selective increased response to a tonal conditioned stimulus (CS) relative to other frequencies, can be induced both by behavioral conditioning and by pairing a tone with stimulation of the nucleus basalis (NB). This study determined whether cortical muscarinic receptors are necessary for NB-induced RF plasticity. Single units in layers II-IV were studied in Urethane anesthetized adult rats. The cortex was perfused with saline or saline+atropine sulfate. Conditioning, 30 trials of pairing a tone with NB stimulation, produced a significant CS-specific response increase (n=8). Local atropine blocked NB-induced RF plasticity, actually resulting in CS-specific response decrease (n=6). Therefore, NB-induced RF plasticity requires engagement of muscarinic receptors in auditory colter. NeuroReport 12:1537-1542 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码：1537 / 1542
页数：6
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