Sonoran propolis:: Chemical composition and antiproliferative activity on cancer cell lines

被引：88

作者：

Hernandez, Javier ^{[2
]}

Goycoolea, Francisco M. ^{[2
]}

Quintero, Jael ^{[1
,2
]}

Acosta, Ana ^{[2
,3
]}

Castaneda, Marco ^{[1
,2
]}

Dominguez, Zaira ^{[6
]}

Robles, Refugio ^{[7
]}

Vazquez-Moreno, Luz ^{[7
]}

Velazquez, Enrique F. ^{[3
]}

Astiazaran, Humberto ^{[4
]}

Lugo, Efrain ^{[2
,5
]}

Velazquez, Carlos ^{[1
]}

机构：

[1] Univ Sonora, Dept Biol Chem, Hermosillo 83000, Sonora, Mexico

[2] Ctr Invest & Alimentac & Desarrollo AC, Biopolymer Lab, Hermosillo, Sonora, Mexico

[3] Univ Sonora, Dept Polymers & Mat, Hermosillo, Sonora, Mexico

[4] Ctr Invest & Alimentac & Desarrollo AC, Dept Nutr, Hermosillo, Sonora, Mexico

[5] Univ Sonora, Dept Ciencias Quim Biol & Agropecuaris, H Caborca, Sonora, Mexico

[6] Univ Veracruzana, Unidad Serv Apoyo & Resoluc Analit, Xalapa 91000, Veracruz, Mexico

[7] Ctr Invest & Alimentac & Desarrollo AC, Dept Food Sci, Hermosillo, Sonora, Mexico

来源：

PLANTA MEDICA | 2007年 / 73卷 / 14期

关键词：

Sonoran propolis; anti proliferative activity; chemical composition;

D O I：

10.1055/s-2007-990244

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In this study, we have analyzed the chemical composition and antiproliferative activity of propolis from three different and and semiarid regions of Sonora, Mexico. We identified and quantitated the main chemical constituents of propolis by HPLC-MS. The most abundant constituents of propolis were pinocembrin, pinobanksin 3-acetate, and chrysin. Sonoran propolis had a strong antiproliferative activity on both murine and human cancer cell lines in a concentration-dependent manner. The propolis constituents CAPE, galangin, xanthomicrol and chrysin showed significant antiproliferative activity on most of the cancer cells tested. DNA harvested from cancer cell cultures treated with Sonoran propolis exhibited a ladder of internucleosomal DNA cleavage characteristic of apoptosis. In summary, we have identified and quantitated the main constituents of Sonoran propolis. These propolis samples possess a strong antiproliferative activity on cancer cell lines.

引用

页码：1469 / 1474

页数：6

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