Synthesis, characterization and in vitro evaluation of cytotoxicity and antibacterial properties of vanadyl complexes of the pyridoxal Schiff bases

被引：5

作者：

Askarian, Saeedeh ^{[1
,2
]}

Beyramabadi, S. Ali ^{[3
]}

Badmasti, Farzad ^{[4
,5
]}

Heravi, Fatemah Sadeghpour ^{[6
]}

Tabrizi, Amir Mohammad Ali ^{[7
]}

Azizi, Hakim ^{[8
]}

Mohaghegh, Mohammad Ali ^{[9
]}

Morsali, Ali ^{[10
]}

Bazian, Atiye ^{[10
]}

Bozorgmehr, Mohammad Reza ^{[3
]}

Azizi, Omid ^{[7
,10
]}

机构：

[1] Torbat Heydariyeh Univ Med Sci, Sch Paramed Sci, Dept Med Biotechnol, Heydariyeh, Iran

[2] Torbat Heydariyeh Univ Med Sci, Sch Med, Neurosci Res Ctr, Heydariyeh, Iran

[3] Islamic Azad Univ, Mashhad Branch, Dept Chem, Mashhad, Iran

[4] Pasteur Inst Iran, Dept Bacteriol, Tehran, Iran

[5] Pasteur Inst Iran, Microbiol Res Ctr MRC, Tehran, Iran

[6] Macquarie Univ, Biomed Sci Dept, N Ryde, NSW, Australia

[7] Torbat Heydariyeh Univ Med Sci, Sch Paramed Sci, Dept Lab Sci, Torbat Heydariyeh, Iran

[8] Zabol Univ Med Sci, Sch Med, Dept Med Parasitol, Zabol, Iran

[9] Torbat Heydariyeh Univ Med Sci, Hlth Sci Res Ctr, Torbat Heydariyeh, Iran

[10] Islamic Azad Univ, Mashhad Branch, Young Researchers & Elite Club, Mashhad, Iran

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2021年 / 1246卷

关键词：

Antimicrobial; Cytotoxicity; Schiff base; Vanadyl complex; Fukui functions; CRYSTAL-STRUCTURE; THEORETICAL CHARACTERIZATIONS; ANTIOXIDANT ACTIVITY; VIBRATIONAL-SPECTRA; MOLECULAR-STRUCTURE; ANTICANCER ACTIVITY; LIGAND SYNTHESIS; MN(II) COMPLEX; FT-IR; CANCER;

D O I：

10.1016/j.molstruc.2021.131189

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In the current study, we synthesized new vanadyl complexes of the N,N'-dipyridoxyl(1,2-propanediamine) Schiff bases and characterized them by experimental and theoretical methods. Also, the antibacterial (against strains of S. aureus, P. aeruginosa and E. coli) and cytotoxicity activities of three V(IV) complexes including VO-EN, VO-13 and VO-12 of the pyridoxal SBs were evaluated against human prostate tumor cells (PC3 cell line), where the VO-EN, VO-13 and VO-12 species are V(IV) complexes of the N,N'-dipyridoxyl(ethylenediamine), N,N'-dipyridoxyl(1,3-propanediamine) and N,N'-dipyridoxyl(1,2-propanediamine) Schiff bases, respectively. Deprotonated form of the N,N'-dipyridoxyl(1,2-propanediamine) Schiff base acts as a tetradentate N2O2 ligand, which coordinates to the V(IV) via two phenolate oxygens and two azomethine nitrogens. In the square-pyramidal geometry of the synthesized complex (VO-12), an oxo ligand occupies the apical position. The analyzed results for the VO-12 complex were in agreement with the experimental tests, confirming the suitability of its optimized geometry. The synthesized VO-12 complex displays significant and reusable catalytic activities in synthesis of the tetrahydrobenzo[b]pyrans, where the V4+ central ion is the active site of the catalyst. All investigated SB complexes were active against P.aeruginosa, while VO-13, VO-12 and VO-EN complexes revealed no activity against E. coli and S. aureus, respectively. All complexes showed considerable cytotoxic against PC3 cells. Our results suggested that these complexes decreased the cell viability after 48 h and the VO-12 complex showed the highest cytotoxicity. These observations suggested that the VO-EN, VO-13 and VO-12 species can be cytotoxic materials for pharmaceutical applications. In addition, in a dose-dependent manner, these compounds can be consider as potent antimicrobial agents. (C) 2021 Elsevier B.V. All rights reserved.

引用

页数：10

共 70 条

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