Epigenetic Mechanisms in Inflammation

被引:211
作者
Bayarsaihan, D. [1 ]
机构
[1] Univ Connecticut, Ctr Hlth, Sch Dent, Ctr Regenerat Med & Skeletal Dev,Dept Reconstruct, Farmington, CT 06030 USA
关键词
epigenetics; histone modifications; DNA methylation; inflammation; NF-KAPPA-B; HELICOBACTER-PYLORI INFECTION; DNA METHYLTRANSFERASES 3A; GENE-EXPRESSION; PROTEIN EZH2; TARGET GENES; HISTONE H3; TNF-ALPHA; METHYLATION; CANCER;
D O I
10.1177/0022034510378683
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Epigenetic modifications occur in response to environmental changes and play a fundamental role in gene expression following environmental stimuli. Major epigenetic events include methylation and acetylation of histones and regulatory factors, DNA methylation, and small non-coding RNAs. Diet, pollution, infections, and other environmental factors have profound effects on epigenetic modifications and trigger susceptibility to diseases. Despite a growing body of literature addressing the role of the environment on gene expression, very little is known about the epigenetic pathways involved in the modulation of inflammatory and anti-inflammatory genes. This review summarizes the current knowledge about epigenetic control mechanisms during the inflammatory response.
引用
收藏
页码:9 / 17
页数:9
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