Antinociceptive effects of supraspinal rat cart (55-102) peptide in mice

被引：18

作者：

Damaj, AI

Martin, BR

Kuhar, MJ

机构：

[1] Virginia Commonwealth Univ, Coll Med, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

[2] Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30329 USA

来源：

BRAIN RESEARCH | 2003年 / 983卷 / 1-2期

关键词：

CART; antinociception; neuropeptide; locomotor activity;

D O I：

10.1016/S0006-8993(03)03094-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the effects of rat cocaine- and amphetamine-regulated transcript CART (55-102) after i.c.v. administration in mouse models of acute and persistent pain. CART was not active in the tail-flick or PPQ tests. It increased the latency to paw licking in the hot-plate test but only at doses that impaired motor function. CART produces antinociception in the formalin test in both phases. Our results suggest that CART is involved in supraspinal pain transmission. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：233 / 236

页数：4

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