Nanopharmaceuticals I: nanocarrier systems in drug delivery

被引：28
作者：
Rhee, Yun-Seok [1 ]
Mansour, Heidi M. [1 ]
机构：
[1] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Drug Dev Div, Lexington, KY 40536 USA
来源：
INTERNATIONAL JOURNAL OF NANOTECHNOLOGY | 2011年 / 8卷 / 1-2期
关键词：
liposomes; polymeric nanoparticles; polymeric micelles; lipid nanoparticles; microemulsions; nanogels; submicron lipid emulsions; SOLID LIPID NANOPARTICLES; INTRANASAL MUCOADHESIVE MICROEMULSIONS; MEDIATED INTRACELLULAR DELIVERY; FREE INTRAVENOUS MICROEMULSIONS; POLYMERIC MICELLE FORMULATION; FEMALE REPRODUCTIVE-TRACT; BLOCK-COPOLYMER MICELLES; DRY POWDER FORMULATIONS; TOPICAL DELIVERY; OCULAR DELIVERY;
D O I：
10.1504/IJNT.2011.037172
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
To achieve maximum pharmacological effects with minimum side effects of drugs, drugs should be delivered to target sites without significant distribution to non-target areas. Using pharmaceutical nanocarrier systems for drug delivery is a useful delivery platform for improving target specificity, therapeutic activity, and reducing toxicity of drugs. Various sophisticated nanocarrier systems have been developed for drug delivery, and this review focuses on liposomes, polymeric nanoparticles, polymeric micelles, lipid nanoparticles, microemulsions, nanogels, and submicron lipid emulsions. This review outlines and explores nanocarrier systems for drug delivery by various administration routes including parenteral, oral, transdermal, pulmonary, ocular, and mucosal and discusses the product development and related issues in nanopharmaceutical drug delivery.
引用
收藏
页码：84 / 114
页数：31
相关论文
共 241 条
[91]   Albumin nanoparticles for the intravitreal delivery of anticytomegaloviral drugs [J].
Irache, JM ;
Merodio, M ;
Arnedo, A ;
Camapanero, MA ;
Mirshahi, M ;
Espuelas, S .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2005, 5 (03) :293-305
[92]   Reversible clustering of pH- and temperature-responsive Janus magnetic nanoparticles [J].
Isojima, Tatsushi ;
Lattuada, Marco ;
Vander Sande, John B. ;
Hatton, T. Alan .
ACS NANO, 2008, 2 (09) :1799-1806
[93]   Application of surface coated liposomes for oral delivery of peptide: Effects of coating the liposome's surface on the GI transit of insulin [J].
Iwanaga, K ;
Ono, S ;
Narioka, K ;
Kakemi, M ;
Morimoto, K ;
Yamashita, S ;
Namba, Y ;
Oku, N .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1999, 88 (02) :248-252
[94]   A study on the influence of emulsion droplet size on the skin penetration of tetracaine [J].
Izquierdo, P. ;
Wiechers, J. W. ;
Escribano, E. ;
Garcia-Celma, M. J. ;
Tadros, T. F. ;
Esquena, J. ;
Dederen, J. C. ;
Solans, C. .
SKIN PHARMACOLOGY AND PHYSIOLOGY, 2007, 20 (05) :263-270
[95]  
Jadhav K. R., 2006, Current Drug Delivery, V3, P267, DOI 10.2174/156720106777731118
[96]   Development and Evaluation of Nitrendipine Nanoemulsion for Intranasal Delivery [J].
Jain, Ratnesh ;
Patravale, Vandana B. .
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2009, 5 (01) :62-68
[97]  
Jamal KN, 2009, CLIN OPHTHALMOL, V3, P381
[98]   Topical delivery of erythromycin from various formulations: An in vivo hairless mouse study [J].
Jayaraman, SC ;
Ramachandran, C ;
Weiner, N .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1996, 85 (10) :1082-1084
[99]   Intranasal mucoadhesive microemulsion of tacrine to improve brain targeting [J].
Jogani, Viral V. ;
Shah, Pranav J. ;
Mishra, Pushpa ;
Mishra, Anil Kumar ;
Misra, Ambikanandan R. .
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2008, 22 (02) :116-124
[100]   Nanostructured lipid carrier (NLC) based gel of celecoxib [J].
Joshi, Medha ;
Patravale, Vandana .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 346 (1-2) :124-132
567891011121314