Nanopharmaceuticals I: nanocarrier systems in drug delivery

被引：28

作者：

Rhee, Yun-Seok ^{[1
]}

Mansour, Heidi M. ^{[1
]}

机构：

[1] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Drug Dev Div, Lexington, KY 40536 USA

来源：

INTERNATIONAL JOURNAL OF NANOTECHNOLOGY | 2011年 / 8卷 / 1-2期

关键词：

liposomes; polymeric nanoparticles; polymeric micelles; lipid nanoparticles; microemulsions; nanogels; submicron lipid emulsions; SOLID LIPID NANOPARTICLES; INTRANASAL MUCOADHESIVE MICROEMULSIONS; MEDIATED INTRACELLULAR DELIVERY; FREE INTRAVENOUS MICROEMULSIONS; POLYMERIC MICELLE FORMULATION; FEMALE REPRODUCTIVE-TRACT; BLOCK-COPOLYMER MICELLES; DRY POWDER FORMULATIONS; TOPICAL DELIVERY; OCULAR DELIVERY;

D O I：

10.1504/IJNT.2011.037172

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

To achieve maximum pharmacological effects with minimum side effects of drugs, drugs should be delivered to target sites without significant distribution to non-target areas. Using pharmaceutical nanocarrier systems for drug delivery is a useful delivery platform for improving target specificity, therapeutic activity, and reducing toxicity of drugs. Various sophisticated nanocarrier systems have been developed for drug delivery, and this review focuses on liposomes, polymeric nanoparticles, polymeric micelles, lipid nanoparticles, microemulsions, nanogels, and submicron lipid emulsions. This review outlines and explores nanocarrier systems for drug delivery by various administration routes including parenteral, oral, transdermal, pulmonary, ocular, and mucosal and discusses the product development and related issues in nanopharmaceutical drug delivery.

引用

页码：84 / 114

页数：31

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