Viral and cellular interactions during adenovirus DNA replication

被引：62
作者：
Charman, Matthew [1 ,2 ,3 ]
Herrmann, Christin [1 ,2 ,4 ]
Weitzman, Matthew D. [1 ,2 ,3 ]
机构：
[1] Childrens Hosp Philadelphia, Div Protect Immun, Philadelphia, PA 19104 USA
[2] Childrens Hosp Philadelphia, Div Canc Pathobiol, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA
[4] Univ Penn, Perelman Sch Med, Cell & Mol Biol Grad Grp, Philadelphia, PA 19104 USA
来源：
FEBS LETTERS | 2019年 / 593卷 / 24期
基金：
美国国家卫生研究院;
关键词：
adenovirus; DNA; liquid-liquid phase separation; viral replication compartment; virus; NUCLEAR FACTOR-I; EARLY GENE-EXPRESSION; CORE PROTEIN-VII; DOUBLE-STRANDED DNA; ACTIVATING FACTOR-I; BINDING-PROTEIN; MESSENGER-RNA; NUCLEOLAR PROTEIN; COMPLEX-FORMATION; IVA2; PROTEIN;
D O I：
10.1002/1873-3468.13695
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adenoviruses represent ubiquitous and clinically significant human pathogens, gene-delivery vectors, and oncolytic agents. The study of adenovirus-infected cells has long been used as an excellent model to investigate fundamental aspects of both DNA virus infection and cellular biology. While many key details supporting a well-established model of adenovirus replication have been elucidated over a period spanning several decades, more recent findings suggest that we have only started to appreciate the complex interplay between viral genome replication and cellular processes. Here, we present a concise overview of adenovirus DNA replication, including the biochemical process of replication, the spatial organization of replication within the host cell nucleus, and insights into the complex plethora of virus-host interactions that influence viral genome replication. Finally, we identify emerging areas of research relating to the replication of adenovirus genomes.
引用
收藏
页码：3531 / 3550
页数：20
相关论文
共 218 条
[1]   ADENOVIRUS PROTEINS ASSOCIATED WITH MESSENGER-RNA AND HNRNA IN INFECTED HELA-CELLS [J].
ADAM, SA ;
DREYFUSS, G .
JOURNAL OF VIROLOGY, 1987, 61 (10) :3276-3283
[2]   Components of Adenovirus Genome Packaging [J].
Ahi, Yadvinder S. ;
Mittal, Suresh K. .
FRONTIERS IN MICROBIOLOGY, 2016, 7
[3]   Adenoviral E2 IVa2 protein interacts with L4 33K protein and E2 DNA-binding protein [J].
Ahi, Yadvinder S. ;
Vemula, Sai V. ;
Mittal, Suresh K. .
JOURNAL OF GENERAL VIROLOGY, 2013, 94 :1325-1334
[4]   Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates [J].
Alberti, Simon ;
Gladfelter, Amy ;
Mittag, Tanja .
CELL, 2019, 176 (03) :419-434
[5]   Drosophila MUS312 and the Vertebrate Ortholog BTBD12 Interact with DNA Structure-Specific Endonucleases in DNA Repair and Recombination [J].
Andersen, Sabrina L. ;
Bergstralh, Daniel T. ;
Kohl, Kathryn P. ;
LaRocque, Jeannine R. ;
Moore, Chris B. ;
Sekelsky, Jeff .
MOLECULAR CELL, 2009, 35 (01) :128-135
[6]   A core viral protein binds host nucleosomes to sequester immune danger signals [J].
Avgousti, Daphne C. ;
Herrmann, Christin ;
Kulej, Katarzyna ;
Pancholi, Neha J. ;
Sekulic, Nikolina ;
Petrescu, Joana ;
Molden, Rosalynn C. ;
Blumenthal, Daniel ;
Paris, Andrew J. ;
Reyes, Emigdio D. ;
Ostapchuk, Philomena ;
Hearing, Patrick ;
Seeholzer, Steven H. ;
Worthen, G. Scott ;
Black, Ben E. ;
Garcia, Benjamin A. ;
Weitzman, Matthew D. .
NATURE, 2016, 535 (7610) :173-+
[7]   EARLY CAPPING OF TRANSCRIPTS FROM THE ADENOVIRUS MAJOR LATE TRANSCRIPTION UNIT [J].
BABICH, A ;
NEVINS, JR ;
DARNELL, JE .
NATURE, 1980, 287 (5779) :246-248
[8]   THE STABILITY OF EARLY ADENOVIRUS MESSENGER-RNA IS CONTROLLED BY THE VIRAL 72KD DNA-BINDING PROTEIN [J].
BABICH, A ;
NEVINS, JR .
CELL, 1981, 26 (03) :371-379
[9]   Designer Oncolytic Adenovirus: Coming of Age [J].
Baker, Alexander T. ;
Aguirre-Hernandez, Carmen ;
Hallden, Gunnel ;
Parker, Alan L. .
CANCERS, 2018, 10 (06)
[10]   SPLICED SEGMENTS AT 5' TERMINUS OF ADENOVIRUS 2 LATE MESSENGER-RNA [J].
BERGET, SM ;
MOORE, C ;
SHARP, PA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (08) :3171-3175
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