Immunosuppression is a Double-Edged Sword in COVID-19 Treatment: a Case Report of Rhino-Orbito-Cerebral Mucormycosis

被引：0

作者：

Sedaghattalab, Moslem ^{[1
]}

Bagheri, Tahmineh ^{[1
]}

Doustimotlagh, Amir H. ^{[2
]}

机构：

[1] Yasuj Univ Med Sci, Dept Internal Med, Yasuj, Iran

[2] Yasuj Univ Med Sci, Med Plants Res Ctr, Yasuj, Iran

来源：

CLINICAL LABORATORY | 2022年 / 68卷 / 07期

关键词：

COVID-19; dexamethasone; mucormycosis; corticoste-roids;

D O I：

10.7754/Clin.Lab.2021.210850)

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Mucormycosis is a life-threatening fungal infection mostly occurring in immunosuppressed patients such as organ transplant or diabetic patients. In this paper, we described a case of COVID-19 with rhino-orbito-cerebral mucormycosis. Methods: The nucleic acid amplification test (NAAT) from a nasopharyngeal sample for SARS-CoV-2 was done. Demographic data, biochemical tests, paranasal sinuses (PNS) CT scan, brain CT scan, chest CT scan, and palate biopsy were performed. Results: The NAAT was positive for SARS-CoV-2. PNS CT scan revealed mucosal thickening of all paranasal si-nuses, brain CT scan showed hypodense area in antero-inferior cortex, and chest CT scan revealed diffuse ground glass opacity in favor of COVID-19 infection. Palate biopsy revealed fibroconnective tissue with broad paucisep-tated ribbon-like hyphae. Conclusions: In this paper, a case of COVID-19 with rhino-orbito-cerebral mucormycosis was described. The treatment with immunosuppressive drugs predisposed this patient to secondary fungal infection. Immunosuppres-sion is a double-edged sword in COVID-19 treatment and immunosuppressive drugs should be prescribed only in severely ill patients and for a short period.

引用

页码：1484 / 1487

页数：4

共 7 条

[1] Diabetes mellitus as the major risk factor for mucormycosis in Mexico: Epidemiology, diagnosis, and outcomes of reported cases [J].