Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface

被引:326
作者
Nancy, Patrice [1 ]
Tagliani, Elisa [1 ]
Tay, Chin-Siean [1 ]
Asp, Patrik [2 ]
Levy, David E. [1 ,2 ]
Erlebacher, Adrian [1 ,2 ]
机构
[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
[2] NYU, Sch Med, Inst Canc, New York, NY 10016 USA
关键词
PREGNANT UTERUS; KAPPA-B; ACTIVATION; SITE; EXPRESSION; LIGAND; GAMMA; CD4; IFN;
D O I
10.1126/science.1220030
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The chemokine-mediated recruitment of effector T cells to sites of inflammation is a central feature of the immune response. The extent to which chemokine expression levels are limited by the intrinsic developmental characteristics of a tissue has remained unexplored. We show in mice that effector T cells cannot accumulate within the decidua, the specialized stromal tissue encapsulating the fetus and placenta. Impaired accumulation was in part attributable to the epigenetic silencing of key T cell-attracting inflammatory chemokine genes in decidual stromal cells, as evidenced by promoter accrual of repressive histone marks. These findings give insight into mechanisms of fetomaternal immune tolerance, as well as reveal the epigenetic modification of tissue stromal cells as a modality for limiting effector T cell trafficking.
引用
收藏
页码:1317 / 1321
页数:5
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