A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster

被引:190
作者
Hao, HP
Allen, DL
Hardin, PE
机构
[1] UNIV HOUSTON,DEPT BIOL,HOUSTON,TX 77204
[2] TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
关键词
D O I
10.1128/MCB.17.7.3687
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Genes expressed under circadian-clock control are found in organisms ranging from prokaryotes to humans, In Drosophila melanogaster, the period (per) gene, which is required for clock function, is transcribed in a circadian manner, We have identified a circadian transcriptional enhancer within a 69-bp DNA fragment upstream of the pel gene, This enhancer drives high-amplitude mRNA cycling under light-dark-cycling or constant-dark conditions, and this activity is per protein (PER) dependent, An E-box sequence within this 69-bp fragment is necessary for high-level expression, but not for rhythmic expression, indicating that PER mediates circadian transcription through other sequences in this fragment.
引用
收藏
页码:3687 / 3693
页数:7
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